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676481 VEGFR Tyrosine Kinase Inhibitor II - CAS 269390-69-4 - Calbiochem

The VEGFR Tyrosine Kinase Inhibitor II, also referenced under CAS 269390-69-4, controls the biological activity of VEGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide, VEGF Receptor Tyrosine Kinase Inhibitor II, VEGFR2 Kinase Inhibitor XVII, VEGFR1 Kinase Inhibitor III

Primary Target: Kinase activities of KDR, Flt-1 and c-Kit
676481
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
269390-69-4C₁₉H₁₆ClN₃O

Products

Catalogue NumberPackaging Qty/Pack
676481-5MG Glass bottle 5 mg
Description
OverviewA pyridinyl-anthranilamide compound that displays both antiangiogenic and antitumor properties. A potent, cell-permeable, reversible, and ATP-competitive inhibitor of the kinase activities of KDR, Flt-1 and c-Kit (IC50 = 20 nM, 180 nM and 240 nM, respectively), and minimally inhibit c-Src and EGF-R activities (IC50 = 7 µM and 7.3 µM). Further, inactive towards the inhibition of CDK-1, c-Met, IGF-1R and PKA (IC50 > 10 µM).
Catalogue Number676481
Brand Family Calbiochem®
SynonymsN-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide, VEGF Receptor Tyrosine Kinase Inhibitor II, VEGFR2 Kinase Inhibitor XVII, VEGFR1 Kinase Inhibitor III
References
ReferencesFuret, P., et al. 2003. Bioorg. Med. Chem. Lett. 13, 2967.
Product Information
CAS number269390-69-4
ATP CompetitiveY
FormWhite solid
Hill FormulaC₁₉H₁₆ClN₃O
Chemical formulaC₁₉H₁₆ClN₃O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetKinase activities of KDR, Flt-1 and c-Kit
Primary Target IC<sub>50</sub>20 nM, 180 nM and 240 nM against kinase activities of KDR, Flt-1 and c-Kit, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
676481-5MG 04055977183610

Documentation

VEGFR Tyrosine Kinase Inhibitor II - CAS 269390-69-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

VEGFR Tyrosine Kinase Inhibitor II - CAS 269390-69-4 - Calbiochem Certificates of Analysis

TitleLot Number
676481

References

Reference overview
Furet, P., et al. 2003. Bioorg. Med. Chem. Lett. 13, 2967.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-January-2010 RFH
SynonymsN-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide, VEGF Receptor Tyrosine Kinase Inhibitor II, VEGFR2 Kinase Inhibitor XVII, VEGFR1 Kinase Inhibitor III
DescriptionA potent, cell-permeable, reversible, and ATP-competitive inhibitor of the kinase activities of KDR, Flt-1 and c-Kit (IC50 = 20 nM, 180 nM and 240 nM, respectively), and minimally inhibit c-Src and EGF-R activities (IC50 = 7.0 µM and 7.3 µM). Also displays antiangiogenic and antitumor properties. Does not inhibit the activities of CDK-1, c-Met, IGF-1R or PKA (IC50 > 10 µM).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number269390-69-4
Chemical formulaC₁₉H₁₆ClN₃O
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (5 mg/ml) or methanol
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesFuret, P., et al. 2003. Bioorg. Med. Chem. Lett. 13, 2967.