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23-057 Smac/DIABLO

Smac/DIABLO MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Enzyme Assays Entrez Gene Number: NM_019887
23-057
10 µg  
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number23-057
Brand Family Upstate
Trade Name
  • Upstate
DescriptionSmac/DIABLO
Alternate Names
  • Diablo homolog, mitochondrial
  • Direct IAP-binding protein with low pI
  • Second mitochondria-derived activator of caspase (Smac)
Background InformationSmac/DIABLO is a mitochondrial protein that is proteolytically processed and released during apoptosis along with cytochrome c and other pro-apoptotic factors. Once in the cytosol, Smac/DIABLO binds to inhibitors of apoptosis (IAP) proteins and disrupts the ability of the IAPs to inhibit caspases 3, 7, and 9 thereby promoting apoptosis. Along with several other pro-apoptotic proteins, Smac/DIABLO has been shown to be a substrate for the ubiquitin ligase XIAP.
References
Product Information
Quality LevelMQ100
Applications
Key Applications
  • Enzyme Assays
Biological Information
Cascade ComponentSubstrate
Entrez Gene Number
Purification MethodPurified using immobilized metal affinity chromatography
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Packaging Information
Material Size10 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
23-057 04053252919060

Related Products & Applications

Alternative Packsize

Catalogue Number Description
23-057M Smac/DIABLO

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Categories

Life Science Research > Proteins and Enzymes > Other Proteins