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551600 Quercetin, Dihydrate - CAS 6151-25-3 - Calbiochem

A cell-permeable and reversible inhibitor of PIM1 kinase (IC₅₀ = 43 nM), PI 3-K (IC₅₀ = 3.8 µM) and phospholipase A2 (IC₅₀ = 2 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3,3ʹ,4ʹ,5,7-Pentahydroxyflavone

Primary Target: PI 3-kinase
551600
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
6151-25-3C₁₅H₁₀O₇ · 2H₂O

Products

Catalogue NumberPackaging Qty/Pack
551600-100MG Glass bottle 100 mg
Description
OverviewA cell-permeable and reversible inhibitor of PIM1 kinase (IC50 = 43 nM), PI 3-K (IC50 = 3.8 µM) and phospholipase A2 (IC50 = 2 µM). Also inhibits mitochondrial ATPase, phosphodiesterases, and protein kinase C. Induces apoptosis in K562, Molt-4, Raji, and MCAS tumor cell lines. Reported to activate sirtuins and promote the survival of eukaryotic cells.
Catalogue Number551600
Brand Family Calbiochem®
Synonyms3,3ʹ,4ʹ,5,7-Pentahydroxyflavone
References
ReferencesBullock, A.N., et al. 2005. J. Med. Chem. 48, 7604.
Howitz, K.T., et al. 2003. Nature 425, 191.
Wei, Y.Q., et al. 1994. Cancer Res. 54, 4952.
Shibasaki, F., et al. 1993. Biochem. J. 289, 227.
Matter, W.F., et al. 1992. Biochem. Biophys. Res. Comm. 186, 624.
Levy, J., et al. 1984. Biochem. Biophys. Res. Commun. 123, 1227.
Graziani, Y., et al. 1983. Eur. J. Biochem. 135, 583.
Gschwendt, M., et al. 1983. Biochem. Biophys. Res. Commun. 117, 444.
Ruckstuhl, M., et al. 1979. Biochem. Pharmacol. 28, 535.
Beretz, A., et al. 1978. Experientia 34, 1054.
Product Information
CAS number6151-25-3
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₅H₁₀O₇ · 2H₂O
Chemical formulaC₁₅H₁₀O₇ · 2H₂O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPI 3-kinase
Primary Target IC<sub>50</sub>43 nM, 3.8 µM, 2 µM against PIM1 kinase, PI 3-K, and phospholipase A2, respectively
Purity>95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSLK8950000
Safety Information
R PhraseR: 25-40

Toxic if swallowed.
Limited evidence of a carcinogenic effect.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
551600-100MG 07790788051426

Documentation

Quercetin, Dihydrate - CAS 6151-25-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Quercetin, Dihydrate - CAS 6151-25-3 - Calbiochem Certificates of Analysis

TitleLot Number
551600

References

Reference overview
Bullock, A.N., et al. 2005. J. Med. Chem. 48, 7604.
Howitz, K.T., et al. 2003. Nature 425, 191.
Wei, Y.Q., et al. 1994. Cancer Res. 54, 4952.
Shibasaki, F., et al. 1993. Biochem. J. 289, 227.
Matter, W.F., et al. 1992. Biochem. Biophys. Res. Comm. 186, 624.
Levy, J., et al. 1984. Biochem. Biophys. Res. Commun. 123, 1227.
Graziani, Y., et al. 1983. Eur. J. Biochem. 135, 583.
Gschwendt, M., et al. 1983. Biochem. Biophys. Res. Commun. 117, 444.
Ruckstuhl, M., et al. 1979. Biochem. Pharmacol. 28, 535.
Beretz, A., et al. 1978. Experientia 34, 1054.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-June-2009 JSW
Synonyms3,3ʹ,4ʹ,5,7-Pentahydroxyflavone
DescriptionA cell-permeable inhibitor of PIM1 kinase (IC50 = 43 nM), PI 3-K (IC50 = 3.8 µM) and phospholipase A2 (IC50 = 2 µM). Also inhibits mitochondrial ATPase, phosphodiesterases, and protein kinase C. Induces apoptosis in K562, Molt-4, Raji, and MCAS tumor cell lines. Reported to activate sirtuins and promote the survival of eukaryotic cells.
FormYellow solid
CAS number6151-25-3
RTECSLK8950000
Chemical formulaC₁₅H₁₀O₇ · 2H₂O
Structure formulaStructure formula
Purity>95% by HPLC
SolubilityAcetic Acid (1 mg/ml), Aqueous Alkali (1 mg/ml), or DMSO (5 mg/ml)
Storage Protect from light
+15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
Toxicity Toxic & Carcinogenic / Teratogenic
Merck USA index14, 8034
ReferencesBullock, A.N., et al. 2005. J. Med. Chem. 48, 7604.
Howitz, K.T., et al. 2003. Nature 425, 191.
Wei, Y.Q., et al. 1994. Cancer Res. 54, 4952.
Shibasaki, F., et al. 1993. Biochem. J. 289, 227.
Matter, W.F., et al. 1992. Biochem. Biophys. Res. Comm. 186, 624.
Levy, J., et al. 1984. Biochem. Biophys. Res. Commun. 123, 1227.
Graziani, Y., et al. 1983. Eur. J. Biochem. 135, 583.
Gschwendt, M., et al. 1983. Biochem. Biophys. Res. Commun. 117, 444.
Ruckstuhl, M., et al. 1979. Biochem. Pharmacol. 28, 535.
Beretz, A., et al. 1978. Experientia 34, 1054.