480065 Sigma-AldrichNecrostatin-1 - CAS 4311-88-0 - Calbiochem
Necrostatin-1, CAS 4311-88-0, is a cell-permeable, potent, and selective blocker of necroptosis (EC₅₀ = 494 nM in FADD-deficient Jurkat cells treated with TNF-α).
More>> Necrostatin-1, CAS 4311-88-0, is a cell-permeable, potent, and selective blocker of necroptosis (EC₅₀ = 494 nM in FADD-deficient Jurkat cells treated with TNF-α). Less<<Necrostatin-1 - CAS 4311-88-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Necrosome Inhibitor I, 5-(Indol-3-ylmethyl)-(2-thio-3-methyl)hydantoin, Nec-1, Methyl-thiohydantoin-tryptophan, MTH-Trp, Receptor-Interacting Protein 1 Inhibitor I, RIPK 1 Inhibitor I, Nec1, RIP1 Inhibitor I, Necrosis Inhibitor II
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 4311-88-0 | C₁₃H₁₃N₃OS |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 480065-5MG | Plastic ampoule | 5 mg |
| Description | |
|---|---|
| Overview | A cell-permeable, potent, and selective blocker of necroptosis (EC50 = 494 nM in FADD-deficient Jurkat cells treated with TNF-α), a nonapoptotic necrotic cell death pathway mediated by death-domain receptors (DRs) that offers neuroprotection in a murine model of ischemic brain injury. Exhibits no effect on DR-induced apoptosis. Also acts as a selective and ATP-competitive inhibitor of RIP1 kinase with negligible effect of RIP2 kinase activity. Nec-1 target appears to be a critical common necroptotic step upstream of execution events and downstream of DRs. Inactive control, Nec-1i, is also available (Cat. No. 480066). Also available as a 25 mM solution in DMSO (Cat. No. 505224). |
| Catalogue Number | 480065 |
| Brand Family | Calbiochem® |
| Synonyms | Necrosome Inhibitor I, 5-(Indol-3-ylmethyl)-(2-thio-3-methyl)hydantoin, Nec-1, Methyl-thiohydantoin-tryptophan, MTH-Trp, Receptor-Interacting Protein 1 Inhibitor I, RIPK 1 Inhibitor I, Nec1, RIP1 Inhibitor I, Necrosis Inhibitor II |
| Product Information | |
|---|---|
| CAS number | 4311-88-0 |
| ATP Competitive | Y |
| Form | Yellow crystalline solid |
| Hill Formula | C₁₃H₁₃N₃OS |
| Chemical formula | C₁₃H₁₃N₃OS |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | Blocker of necroptosis |
| Primary Target IC<sub>50</sub> | EC50 = 494 nM in blocking necrosis in FADD-deficient Jurkat cells treated with TNF-α |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 480065-5MG | 04055977201871 |