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454126 Methotrexate - CAS 59-05-2 - Calbiochem

454126
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Overview

Key Spec Table

CAS #Empirical Formula
59-05-2C₂₀H₂₂N₈O₅ • 3H₂O

Products

Catalogue NumberPackaging Qty/Pack
454126-100MG Glass bottle 100 mg
Description
OverviewInhibits thymidylate synthetase, is a nonselective de novo purine synthesis inhibitor, and has a significant toxicity profile including hepatotoxicity, pneumonitis, and bone marrow suppression. Potent folic acid antagonist. Induces apoptosis in HL-60 human leukemia cells. Also useful as an antitumor agent.
Catalogue Number454126
Brand Family Calbiochem®
References
ReferencesKaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
Takasuga, A., et al. 1992. J. Biochem. 112, 652.
Hirata, S., et al. 1989. Arthritis Rheum. 32, 1065.
Jolivet, J., et al. 1983. New Engl. J. Med. 309, 1094.
Product Information
CAS number59-05-2
FormYellow solid
Hill FormulaC₂₀H₂₂N₈O₅ • 3H₂O
Chemical formulaC₂₀H₂₂N₈O₅ • 3H₂O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥98% by HPLC
Safety Information
R PhraseR: 23/24/25-36/37/38-45-46

Toxic by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
May cause cancer.
May cause heritable genetic damage.
S PhraseS: 22-24/25-36/37/39

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
454126-100MG 04055977204711