444966 Sigma-AldrichMEK1/2 Inhibitor III - CAS 391210-10-9 - Calbiochem
MEK1/2 Inhibitor III, CAS 391210-10-9, is a cell-permeable, non-competitive, highly potent MEK/MAPKK/MKK inhibitor that blocks cellular Erk1/2 phosphorylation (IC50 = 25 in serum starved HeLa cells).
More>> MEK1/2 Inhibitor III, CAS 391210-10-9, is a cell-permeable, non-competitive, highly potent MEK/MAPKK/MKK inhibitor that blocks cellular Erk1/2 phosphorylation (IC50 = 25 in serum starved HeLa cells). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: PD325901, PD0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD 0325901, MEK Inhibitor III
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 391210-10-9 | C₁₆H₁₄F₃IN₂O₄ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 444966-5MG | Plastic ampoule | 5 mg |
| Description | |
|---|---|
| Overview | A cell-permeable benzamide compound that acts as a non-competitive, highly potent, selective MEK/MAPKK/MKK inhibitor and effectively blocks cellular Erk1/2 phosphorylation (by >90% in serum-starved HeLa after serum-stimulation and 50% in C26 with 25 and 0.33 nM inhibitor, respectively), while exhibiting little or no effect against the activity of Erk1/2 or a panel of 66 other kinases even at concentrations as high as 10 µM in cell-free kinase assays. Shown to be orally available in mice and suppress both the growth of and Erk phosphorylation in BRAF(V600E)-expressing SKMEL28 cell-derived tumor in vivo. Also available in InSolution™ format (Cat. No. 444968). |
| Catalogue Number | 444966 |
| Brand Family | Calbiochem® |
| Synonyms | PD325901, PD0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD 0325901, MEK Inhibitor III |
| Product Information | |
|---|---|
| CAS number | 391210-10-9 |
| Form | White to off-white solid |
| Hill Formula | C₁₆H₁₄F₃IN₂O₄ |
| Chemical formula | C₁₆H₁₄F₃IN₂O₄ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Purity | ≥95% by HPLC |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 444966-5MG | 04055977204520 |