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420136 JNK Inhibitor IX - CAS 312917-14-9 - Calbiochem

The JNK Inhibitor IX, also referenced under CAS 312917-14-9, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applic

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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-1-naphthamide

Primary Target: JNK2 and JNK3
420136
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Overview

Key Spec Table

CAS #Empirical Formula
312917-14-9C₂₀H₁₆N₂OS • H₂O

Products

Catalogue NumberPackaging Qty/Pack
420136-5MG Plastic ampoule 5 mg
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Description
OverviewA thienylnaphthamide compound that acts as a potent and ATP binding site-targeting inhibitor of JNK2 and JNK3 (pIC50 = 6.5 and 6.7, respectively) with little or no activity against JNK1, p38α, and a panel of more than 30 other kinases (pIC50 <5.0). In contrast, SP600125 (Cat. Nos. 420119 and 420128) offers little selectivity between JNK1 and JNK3 (pIC50 = 6.4 and 5.9, respectively) under the same assay conditions.
Catalogue Number420136
Brand Family Calbiochem®
SynonymsN-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-1-naphthamide
References
ReferencesAngell, R.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1296.
Product Information
CAS number312917-14-9
ATP CompetitiveY
FormTan solid
Hill FormulaC₂₀H₁₆N₂OS • H₂O
Chemical formulaC₂₀H₁₆N₂OS • H₂O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetJNK2 and JNK3
Primary Target IC<sub>50</sub>pIC50 = 6.5 and 6.7, against JNK2 and JNK3, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
420136-5MG 04055977187663