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662009 InSolution™ U0126 - CAS 109511-58-2 - Calbiochem

A potent and specific inhibitor of MEK1 and MEK2 .

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
662009
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
109511-58-2C₁₈H₁₆N₆S₂•½C₂H₅OH

Products

Catalogue NumberPackaging Qty/Pack
662009-5MG Glass bottle 5 mg
Description
OverviewA potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK. Has very little effect on other kinases such as Abl, Cdk2, Cdk4, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, PKC, and Raf. Also acts as an immunosuppressant by effectively blocking IL-2 synthesis and T cell proliferation without affecting the long-term outcomes of either T cell activation or tolerance. Reported to undergo rapid isomerization in DMSO and exist as an equilibrium mixture of (Z,Z), E,E) and (Z,E) isomers with minimal loss of activity over a period of 1 month.
Catalogue Number662009
Brand Family Calbiochem®
References
ReferencesDuncia, J.V., et al. 1998. Bioorg. Med. Chem. Lett. 8, 2839.
Product Information
CAS number109511-58-2
FormLiquid
FormulationA 100 mM (5 mg/124 µl) solution of U0126 (Cat. No. 662005) in DMSO.
Hill FormulaC₁₈H₁₆N₆S₂•½C₂H₅OH
Chemical formulaC₁₈H₁₆N₆S₂•½C₂H₅OH
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot into precooled vials, freeze immediately at (-70°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
662009-5MG 04055977261035

Documentation

InSolution™ U0126 - CAS 109511-58-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ U0126 - CAS 109511-58-2 - Calbiochem Certificates of Analysis

TitleLot Number
662009

References

Reference overview
Duncia, J.V., et al. 1998. Bioorg. Med. Chem. Lett. 8, 2839.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-January-2012 RFH
DescriptionA potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK. Has very little effect on other kinases such as Abl, Cdk2, Cdk4, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, PKC, and Raf. Also acts as an immunosuppressant by effectively blocking IL-2 synthesis and T cell proliferation without affecting the long-term outcomes of either T cell activation or tolerance. Reported to undergo rapid isomerization in DMSO and exist as an equilibrium mixture of (Z,Z), E,E) and (Z,E) isomers with minimal loss of activity over a period of 1 month.
FormLiquid
FormulationA 100 mM (5 mg/124 µl) solution of U0126 (Cat. No. 662005) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number109511-58-2
Chemical formulaC₁₈H₁₆N₆S₂•½C₂H₅OH
Structure formulaStructure formula
Purity≥98% by HPLC
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot into precooled vials, freeze immediately at (-70°C).
Toxicity Irritant
ReferencesDuncia, J.V., et al. 1998. Bioorg. Med. Chem. Lett. 8, 2839.