553512 Sigma-AldrichInSolution™ Rac1 Inhibitor II, Z62954982 - CAS 1090893-12-1 - Calbiochem
The InSolution™ Rac1 Inhibitor II, Z62954982, also referenced under CAS 1090893-12-1, controls the biological activity of Rac1. This small molecule/inhibitor is primarily used for Phosphorylation &
More>> The InSolution™ Rac1 Inhibitor II, Z62954982, also referenced under CAS 1090893-12-1, controls the biological activity of Rac1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Z62954982, 3-((3,5-Dimethylisoxazol-4-yl)methoxy)-N-(4-methyl-3-sulfamoyl-phenyl)benzamide
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 1090893-12-1 | C₂₀H₂₁N₃O₅S |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 553512-10MG | Glass bottle | 10 mg |
| Description | |
|---|---|
| Overview | A cell-permeable isoxazolyl-benzamide compound that is more effective than NSC23766 (Cat. Nos. 553502 & 553508) in inhibiting PDGF-BB- (Cat. No. 521225) induced cellular Rac1 activation (45.8% vs 11.1% inhibition by 4 h pretreatment of the respective compound at 50 µM) in serum-starved SMCs (human aortic smooth muscle cells) by interfering Rac1-Tiam1 interaction, while exhibiting no effect toward cellular Cdc42 and RhoA activation or Rac1 interaction to its effector Pak1. Shown to effectively prevent PDGF-BB-induced membrane ruffling and lamellipodia formation in serum-starved 3T3 cells (4 h pretreatment at 25 µM). The solid form of this compound (Cat. No. 553511) is also available. |
| Catalogue Number | 553512 |
| Brand Family | Calbiochem® |
| Synonyms | Z62954982, 3-((3,5-Dimethylisoxazol-4-yl)methoxy)-N-(4-methyl-3-sulfamoyl-phenyl)benzamide |
| References | |
|---|---|
| References | Ferri, N., et al. 2009. J. Med. Chem. 52, 4087. |
| Product Information | |
|---|---|
| CAS number | 1090893-12-1 |
| Form | Liquid |
| Formulation | A 100 mM (10 mg/241 µl) solution of Rac1 Inhibitor II, Z62954982 (Cat. No. 553511) in DMSO |
| Hill Formula | C₂₀H₂₁N₃O₅S |
| Chemical formula | C₂₀H₂₁N₃O₅S |
| Hygroscopic | Hygroscopic |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Purity | ≥93% by HPLC |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 553512-10MG | 04055977193718 |