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361515 Glycogen Phosphorylase Inhibitor - CAS 648926-15-2 - Calbiochem

361515
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Overview

Key Spec Table

CAS #Empirical Formula
648926-15-2C₁₇H₁₅ClF₂N₄O₄

Products

Catalogue NumberPackaging Qty/Pack
361515-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable urea compound that acts as a potent and AMP-competitive inhibitor of glycogen phosphorylase (GP; IC50 = 53 nM). Shown to inhibit glucagon-induced glyocgenolysis both in hepatocytes (IC50 = 380 nM) in vitro and in rats (5 mg/kg, iv) in vivo.
Catalogue Number361515
Brand Family Calbiochem®
Synonyms1-(3-(3-(2-Chloro-4,5-difluorobenzoyl)ureido)-4-methoxyphenyl)-3-methylurea
References
ReferencesKlabunde, T., et al. 2005. J. Med. Chem. 48, 6178
Product Information
CAS number648926-15-2
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₇H₁₅ClF₂N₄O₄
Chemical formulaC₁₇H₁₅ClF₂N₄O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetGlycogen phosphorylase
Primary Target IC<sub>50</sub>53 nM against glycogen phosphorylase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
361515-1MG 04055977192902