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361559 GSK-3 Inhibitor XVI - CAS 252917-06-9 - Calbiochem

GSK-3 Inhibitor XVI - CAS 252917-06-9, is a cell-permeable, potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC₅₀ = 10 and 6.7 nM against GSK-3α and GSK-3β, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CHIR99021, 6-(2-(4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino)ethyl-amino)-nicotinonitrile

361559
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
252917-06-9C₂₂H₁₈Cl₂N₈

Products

Catalogue NumberPackaging Qty/Pack
361559-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable aminopyrimidine compound that acts as potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC50 = 10 and 6.7 nM against GSK-3α and GSK-3β, respectively). Exhibits little or no activity toward 46 other enzymes (IC50 >8.8 µM against 20 kinases and Ki ≥5 µM against 23 non-kinase enzymes) and shows only weak binding to 22 pharmacologically relevant receptors (Kd ~4 µM). This compound is orally available and is shown to effectively improve glucose metabolism in both murine and rat type 2 diabetes models in vivo. Also available as a 25 mM solution in DMSO (Cat. No. 361571).
Catalogue Number361559
Brand Family Calbiochem®
SynonymsCHIR99021, 6-(2-(4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino)ethyl-amino)-nicotinonitrile
References
ReferencesMussmann, R., et al. 2007. J. Biol. Chem. 282, 12030.
Ring, D.B., et al. 2003. Diabetes 52, 588.
Bennett, C.N., et al. 2002. J. Biol. Chem. 277, 30998.
Cline, G.W., et al. 2002. Diabetes 51, 2903.
Product Information
CAS number252917-06-9
FormWhite to beige solid
Hill FormulaC₂₂H₁₈Cl₂N₈
Chemical formulaC₂₂H₁₈Cl₂N₈
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 22-24/25-36-45

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
361559-5MG 04055977214208

Documentation

GSK-3 Inhibitor XVI - CAS 252917-06-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

GSK-3 Inhibitor XVI - CAS 252917-06-9 - Calbiochem Certificates of Analysis

TitleLot Number
361559

References

Reference overview
Mussmann, R., et al. 2007. J. Biol. Chem. 282, 12030.
Ring, D.B., et al. 2003. Diabetes 52, 588.
Bennett, C.N., et al. 2002. J. Biol. Chem. 277, 30998.
Cline, G.W., et al. 2002. Diabetes 51, 2903.

Data Sheet

Title
Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-June-2020 JSW
SynonymsCHIR99021, 6-(2-(4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino)ethyl-amino)-nicotinonitrile
DescriptionA cell-permeable aminopyrimidine compound that acts as potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC50 = 10 and 6.7 nM against GSK-3α and GSK-3β, respectively). CHIR99021 exhibits little or no activity toward 46 other enzymes (IC50 >8.8 µM against 20 kinases and Ki ≥5 µM against 23 non-kinase enzymes) and shows only weak binding to 22 pharmacologically relevant receptors (Kd ~4 µM). CHIR99021 is orally available and is shown to effectively improve glucose metabolism in both murine and rat type 2 diabetes models in vivo.
FormWhite to beige solid
Intert gas (Yes/No) Packaged under inert gas
CAS number252917-06-9
Chemical formulaC₂₂H₁₈Cl₂N₈
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Harmful
ReferencesMussmann, R., et al. 2007. J. Biol. Chem. 282, 12030.
Ring, D.B., et al. 2003. Diabetes 52, 588.
Bennett, C.N., et al. 2002. J. Biol. Chem. 277, 30998.
Cline, G.W., et al. 2002. Diabetes 51, 2903.