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344281 Forskolin, NKH477 - CAS 138605-00-2 - Calbiochem

A cell-permeable and water-soluble Forskolin derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-(3-Dimethylaminopropionyl)forskolin, HCl, Colforsin Daropate, HCl

344281
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
138605-00-2C₂₇H₄₃NO₈ • HCl

Products

Catalogue NumberPackaging Qty/Pack
344281-5MG 5 mg
Description
OverviewA cell-permeable and water-soluble Forskolin (Cat. No. 344270) derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC (1.04- & 0.89-fold relative to Forskolin). NKH477 is shown to be orally available, blood-brain barrier permeant, and display reactivity toward a broad-spectrum of species, including human, canine, guinea pig, murine, procine, and rat.
Catalogue Number344281
Brand Family Calbiochem®
Synonyms6-(3-Dimethylaminopropionyl)forskolin, HCl, Colforsin Daropate, HCl
References
ReferencesNakashima, S., et al. 2005. J. Heart Lung Transplant. 24, 462.
Morinobu, S., et al. 1999. J. Neurochem. 72, 2198.
Satake, K., et al. 1998. Br. J. Pharmacol. 123, 753.
Toya, Y., et al. 1998. J. Mol. Cell Cardiol. 30, 97.
Takeuchi, M., et al. 1995. Cardiovasc. Drug Rev. 13, 339.
Hosono, M., et al. 1992. J. Cardiovasc. Pharmacol. 19, 625.
Shafiq, J., et al. 1992. Circ. Res. 71, 70.
Hosono, M., et al. 1990. Eur. J. Pharmacol. 183, 2110.
Product Information
CAS number138605-00-2
FormWhite solid
Hill FormulaC₂₇H₄₃NO₈ • HCl
Chemical formulaC₂₇H₄₃NO₈ • HCl
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 26/27/28-62-63

Very toxic by inhalation, in contact with skin and if swallowed.
Possible risk of impaired fertility.
Possible risk of harm to the unborn child.
S PhraseS: 22-24/25-36/37/39-45

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
344281-5MG 04055977214673

Documentation

Forskolin, NKH477 - CAS 138605-00-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Forskolin, NKH477 - CAS 138605-00-2 - Calbiochem Certificates of Analysis

TitleLot Number
344281

References

Reference overview
Nakashima, S., et al. 2005. J. Heart Lung Transplant. 24, 462.
Morinobu, S., et al. 1999. J. Neurochem. 72, 2198.
Satake, K., et al. 1998. Br. J. Pharmacol. 123, 753.
Toya, Y., et al. 1998. J. Mol. Cell Cardiol. 30, 97.
Takeuchi, M., et al. 1995. Cardiovasc. Drug Rev. 13, 339.
Hosono, M., et al. 1992. J. Cardiovasc. Pharmacol. 19, 625.
Shafiq, J., et al. 1992. Circ. Res. 71, 70.
Hosono, M., et al. 1990. Eur. J. Pharmacol. 183, 2110.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-August-2010 RFH
Synonyms6-(3-Dimethylaminopropionyl)forskolin, HCl, Colforsin Daropate, HCl
DescriptionA cell-permeable and water-soluble Forskolin (Cat. No. 344270) derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC (1.04- & 0.89-fold relative to Forskolin). NKH477 is shown to be orally available, blood-brain barrier permeant, and display reactivity toward a broad-spectrum of species, including human, canine, guinea pig, murine, procine, and rat.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number138605-00-2
Chemical formulaC₂₇H₄₃NO₈ • HCl
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityH₂O (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Highly Toxic
ReferencesNakashima, S., et al. 2005. J. Heart Lung Transplant. 24, 462.
Morinobu, S., et al. 1999. J. Neurochem. 72, 2198.
Satake, K., et al. 1998. Br. J. Pharmacol. 123, 753.
Toya, Y., et al. 1998. J. Mol. Cell Cardiol. 30, 97.
Takeuchi, M., et al. 1995. Cardiovasc. Drug Rev. 13, 339.
Hosono, M., et al. 1992. J. Cardiovasc. Pharmacol. 19, 625.
Shafiq, J., et al. 1992. Circ. Res. 71, 70.
Hosono, M., et al. 1990. Eur. J. Pharmacol. 183, 2110.