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341207 ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem

341207
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Overview

Key Spec Table

CAS #Empirical Formula
70641-51-9C₂₇H₅₈NO₆P

Products

Catalogue NumberPackaging Qty/Pack
341207-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC50 = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Promotes apoptosis in mitogen-activated, but not resting, T lymphocytes in a dose- and time-dependent manner. Also promotes rapid and selective apoptosis in human leukemic cells.
Catalogue Number341207
Brand Family Calbiochem®
SynonymsEdelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine
References
ReferencesHarguindey, J., et al. 2000. Apoptosis 5, 87.
Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
Helfman, D., et al. 1993. Cancer Res. 53, 2955.
Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
Powis, G., et al. 1992. Cancer Res. 52, 2835.
Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.
Product Information
CAS number70641-51-9
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₇H₅₈NO₆P
Chemical formulaC₂₇H₅₈NO₆P
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetPI-PLC
Primary Target IC<sub>50</sub>9.6 µM against phosphatidylinositol-specific phospholipase C (PI-PLC)
Purity≥95% by TLC
Physicochemical Information
Cell permeableY
Safety Information according to GHS
RTECSYK0718000
Safety Information
R PhraseR: 40

Limited evidence of a carcinogenic effect.
S PhraseS: 22-36

Do not breathe dust.
Wear suitable protective clothing.
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution in ethanol, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.
Global Trade Item Number
Catalogue Number GTIN
341207-5MG 04055977215441