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SCT055 BioTracker Cys Hcy GSH Live Cell Dye Probe1

Live cell imaging dye to simultaneously report for cellular levels of Glutathione (GSH), Cysteine (Cys) and Homocysteine (Hcy) which are inter-related and implicated in several diseases.

SCT055
1 mg  
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue NumberSCT055
DescriptionBioTracker Cys Hcy GSH Live Cell Dye Probe1
OverviewBiological thiols, such as cysteine (Cys), homocysteine (Hcy) and glutathione (GSH), play crucial roles in many physiological and pathological processes. GSH is the most abundant intracellular thiol and plays a central role in combating oxidative stress. Cys is an essential amino acid that is involved in protein synthesis, detoxication, and metabolism. Suboptimal levels of GSH and Cys is involved in several diseases. Elevated plasma total Hcy levels have been established as an independent risk factor for cardiovascular diseases, Alzheimer's disease, neural tube defects, and other diseases.

The BioTracker Cys Hcy GSH triple live cell dye can be used for simultaneous detection of GSH and Cys/Hcy in living cells and tissues. GSH is detected in the red channel while Cys/Hcy are detected in the blue channel.

Spectral Properties
Absorption: 365 nm
Emissions: GSH detection: 587 nm
Emissions: Cys/Hcy detection: 454 nm

References
Yang XF et al. A dual emission fluorescent probe enables simultaneous detection of glutathione and
cysteine/homocysteine. Chem. Sci., 2014, 5, 2177.
Alternate Names
  • Live cell imaging probe
References
Product Information
Detection methodFluorescence
PresentationLyophilized
Applications
ApplicationLive cell imaging dye to simultaneously report for cellular levels of Glutathione (GSH), Cysteine (Cys) and Homocysteine (Hcy) which are inter-related and implicated in several diseases.
Key Applications
  • Cell Based Assays
Application NotesLive cell fluorescent imaging
Biological Information
ConcentrationPlease refer to lot specific datasheet.
Molecular Weight706.68 g/mol
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssurancePurity: ≥ 98% confirmed by HNMR, LC-MS and HPLC and elemental analysis
Molar Mass: 706.68 g/mol
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore BioTracker Cys Hcy GSH Live Cell Dye at -20°C, desiccate and protect from light
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
Packaging Information
Material Size1 mg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
SCT055 04054839008436