182516 Sigma-AldrichArp2/3 Complex Inhibitor II, CK-869 - CAS 388592-44-7 - Calbiochem
The Arp2/3 Complex Inhibitor II, CK-869 controls the biological activity of Arp2/3. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The Arp2/3 Complex Inhibitor II, CK-869 controls the biological activity of Arp2/3. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Actin Assembly Inhibitor XIV, 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-one, racemic, CK-0157869
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 388592-44-7 | C₁₇H₁₆BrNO₃S |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 182516-25MG | Glass bottle | 25 mg |
| Description | |
|---|---|
| Overview | A cell-permeable thiazolidinone compound that inhibits actin assembly mediated by actin-related protein Arp2/3 complex of human and bovine, but not yeast, species (IC50 = 11 µM against bovine Arp2/3). Shown to inhibit the actin filament "comet tails" formation around intracellular Listeria in infected SKOV3 cells (IC50 = 7 µM). Structrual studies indicate that CK-869 targets the hydrophobic core in subdomain 1 of Arp3. CK-666 (Cat. No. 182515) and CK-869 exhibit different modes of binding, resulting in their different yeast cross-reactivities. Supplied as a racemic mixture of the active 2S and the inactive 2R enantiomers. CK-312 (Cat. No. 182518) can serve as a negative control. |
| Catalogue Number | 182516 |
| Brand Family | Calbiochem® |
| Synonyms | Actin Assembly Inhibitor XIV, 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-one, racemic, CK-0157869 |
| References | |
|---|---|
| References | Nolen, B.J., et al. 2009. Nature 460, 1031. |
| Product Information | |
|---|---|
| CAS number | 388592-44-7 |
| Form | Off-white solid |
| Hill Formula | C₁₇H₁₆BrNO₃S |
| Chemical formula | C₁₇H₁₆BrNO₃S |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Purity | ≥95% by HPLC |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 182516-25MG | 04055977205060 |