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MAB2609 Anti-beta Arrestin 1 Antibody, clone 3H11.2

Anti-beta Arrestin 1 Antibody, clone 3H11.2 detects level of beta Arrestin 1 & has been published & validated for use in WB & IF.

Anti-beta Arrestin 1 Antibody, clone 3H11.2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Sensory & PNS, G-proteins Gene Symbol: ARRESTIN, S-AG, S-arrestin UniProt Number: P49407
MAB2609
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IFMPurifiedMonoclonal Antibody
Description
Catalogue NumberMAB2609
DescriptionAnti-beta Arrestin 1 Antibody, clone 3H11.2
Alternate Names
  • Retinal S-antigen
  • Rod photoreceptor arrestin
  • S-antigen
  • retina and pineal gland (arrestin)
  • arrestin 1
  • retinal S-antigen (48 KDa protein)
Background InformationThe Arrestin family consists of four members: Arrestin 1 (visual Arrestin), Arrestin 2 (beta Arrestin 1), Arrestin 3 (beta Arrestin 2), and Arrestin 4 (cone Arrestin). While visual and cone Arrestins are found almost exclusively in the retina, beta Arrestins 1 and 2 are ubiquitously expressed. Beta Arrestins appear to act as negative regulators on G protein-coupled receptors, (Lefkowitz, 1998). Interaction with molecules such as clathrin, AP-2 and NSF directs the clathrin-mediated internalization of G-protein-coupled receptors. Interaction with molecules such as Src, Raf, Erk, ASK1 and JNK3 appears to regulate several pathways that result in the activation of MAP kinases, (Lin, 1998; Miller, 2001).
References
Product Information
FormatPurified
Control
  • HEK293 cell lysate
PresentationPurified in PBS with 0.05% NaN3.
Quality LevelMQ100
Applications
ApplicationAnti-beta Arrestin 1 Antibody, clone 3H11.2 detects level of beta Arrestin 1 & has been published & validated for use in WB & IF.
Key Applications
  • Western Blotting
  • Immunofluorescence
Biological Information
ImmunogenKLH conjugated synthetic peptide corresponding to amino acids 357-372 of human beta arrestin 1.
Epitopea.a. 357-372
Cloneclone 3H11.2
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityReacts with human beta-arrestin 1.
IsotypeIgMκ
Species Reactivity
  • Human
Species Reactivity NoteReacts with human. Other species have not been tested.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryMembers of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. [provided by RefSeq]
Gene Symbol
  • ARRESTIN
  • S-AG
  • S-arrestin
UniProt Number
UniProt SummaryFUNCTION: Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.
SEQUENCE SIMILARITIES: Belongs to the arrestin family.
Molecular Weight~47 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated on a representative lot by Western blot in HEK293 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MAB2609 04053252358982

Documentation

Anti-beta Arrestin 1 Antibody, clone 3H11.2 SDS

Title

Safety Data Sheet (SDS) 

Anti-beta Arrestin 1 Antibody, clone 3H11.2 Certificates of Analysis

TitleLot Number
Anti-beta Arrestin 1, clone 3H11.2 Monoclonal Antibody - 2120062 2120062
Anti-beta Arrestin 1, clone 3H11.2 Monoclonal Antibody - 2390578 2390578
Anti-beta Arrestin 1, clone 3H11.2 - 2433495 2433495
Anti-beta Arrestin 1, clone 3H11.2 - 2246812 2246812
Anti-beta Arrestin 1, clone 3H11.2 - 3123692 3123692
Anti-beta Arrestin 1, clone 3H11.2 - 3688992 3688992
Anti-beta Arrestin 1, clone 3H11.2 - 3800097 3800097
Anti-beta Arrestin 1, clone 3H11.2 - 3852796 3852796
Anti-beta Arrestin 1, clone 3H11.2 - JBC1793819 JBC1793819
Anti-beta Arrestin 1, clone 3H11.2 - NG1604143 NG1604143
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