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ABN1734 Anti-SNAT2

Anti-SNAT2, Cat. No. ABN1734, is a highly specific rabbit polyclonal antibody that targets Sodium-coupled neutral amino acid transporter 2 and has been tested in Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blotting.

ABN1734
100 µL  
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Overview

Replacement Information
Description
Catalogue NumberABN1734
DescriptionAnti-SNAT2
Alternate Names
  • Sodium-coupled neutral amino acid transporter 2
  • Amino acid transporter A2
  • Solute carrier family 38 member 2
  • System A amino acid transporter 2
  • System A transporter 1
  • System N amino acid transporter 2
Background InformationSodium-coupled neutral amino acid transporter 2 (UniProt: Q9JHE5; also known as Amino acid transporter A2, Solute carrier family 38 member 2, System A amino acid transporter 2, System A transporter 1, System N amino acid transporter 2) is encoded by the Scl38a2 (also known as Ata2, Sa1, Sat2, Snat2) gene (Gene ID: 29642) in rat. Sodium-coupled neutral amino acid transporter 2 is a multi-pass membrane protein that functions as a sodium-dependent amino acid transporter and mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. It may also function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta. Its transport action is reported to be inhibited by N-methyl-D-glucamine and choline. It is enriched in the somatodendritic compartment of neurons and is also detected at the axonal shaft, but is excluded from the nerve terminal. It is also expressed in skeletal muscle and adipose tissue. Its levels are up-regulated upon amino acid deprivation that results from increased transcription and protein stabilization.
References
Product Information
FormatUnpurified
PresentationRabbit polyclonal antiserum with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-SNAT2, Cat. No. ABN1734, is a highly specific rabbit polyclonal antibody that targets Sodium-coupled neutral amino acid transporter 2 and has been tested in Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blotting.
Key Applications
  • Immunohistochemistry
  • Western Blotting
  • Immunocytochemistry
  • Immunofluorescence
Application NotesImmunofluorescence Analysis: A 1:150 dilution from a representative lot detected SNAT2 in rat cerebral cortex and human cerebellum tissue sections.

Immunocytochemistry Analysis: A representative lot detected SNAT2 in Immunocytochemistry applications (Grewal, S., et. al. (2009). J Biol Chem. 284(17):11224-36).

Western Blotting Analysis: A representative lot detected SNAT2 in Western Blotting applications (Yao, D., et. al. (2000). J Biol Chem. 275(30):22790-7; Melone, M., et. al. (2006). Neuroscience. 140(1):281-92; Grewal, S., et. al. (2009). J Biol Chem. 284(17):11224-36).

Immunohistochemistry Analysis: A representative lot detected SNAT2 in Immunohistochemistry applications (Melone, M., et. al. (2006). Neuroscience. 140(1):281-92).
Biological Information
ImmunogenGST-tagged recombinant fragment corresponding to the first 65 amino acids from te N-terminal region of rat Sodium-coupled neutral amino acid transporter 2 (SNAT2).
EpitopeN-terminus
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityThis polyclonal antibody detects sodium-coupled neutral amino acid transporter 2 (SNAT2) in rat brain. It targets an epitope within the first 65 amino acids.
IsotypeIgG
Species Reactivity
  • Rat
Species Reactivity NoteRat.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • Slc38a2
  • Ata2
  • Sa1
  • Sat2
  • Snat2
Purification MethodUnpurified
UniProt Number
Molecular Weight55.55 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunofluorescence in rat brain sections.

Immunofluorescence Analysis: A 1:150 dilution of this antibody detected SNAT2 in rat brain tissue sections.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABN1734 04054839233111

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