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ABS1016 Anti-PAS Kinase Antibody

Anti-PAS Kinase Antibody is an antibody against PAS Kinase for use in Western Blotting, Immunohistochemistry .

Anti-PAS Kinase Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: PASK, KIAA0135 UniProt Number: Q96RG2
ABS1016
100 μg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, RWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABS1016
DescriptionAnti-PAS Kinase Antibody
Alternate Names
  • PAS domain-containing serine/threonine-protein kinase
  • PAS Kinase
  • PAS-kinase
  • PASKIN
  • hPASK
Background InformationPAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1; UniProt Q96RG2; also known as hPASK, PASKIN, PAS-kinase, Per-arnt-sim domain kinase) is encoded by the PASK (Also known as KIAA0135, STK37) gene in human (Gene ID 23178). PAS-kinase is a serine/threonine-protein kinase involved in energy homeostasis. Hepatic PASK expression is shown to be induced upon feeding and insulin stimulation, and PASK is reported to be essential for the proteolytic maturation of the transcription factor SREBP-1c in cultured cells and in the mouse and rat liver. SREBP-1c hyperactivation leads to excess hepatic fatty acids and triglycerides synthesis, which has been implicated as a causal feature of metabolic syndrome. PASK inhibition improves lipid and glucose metabolism in dietary animal models of obesity and dyslipidemia. PASK is also involved in protein translation regulation and is shown to phosphorylate eukaryotic translation elongation factor eEF1A1.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ300
Applications
ApplicationAnti-PAS Kinase Antibody is an antibody against PAS Kinase for use in Western Blotting, Immunohistochemistry .
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected PAS Kinase in rat testis tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human PAS Kinase near the C-terminus.
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityThis antibody is expected to detect all three splced isoforms.
Species Reactivity
  • Human
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • PASK
  • KIAA0135
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~160 kDa observed. Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in HEK293 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected PAS Kinase in 50 µg of HEK293 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABS1016 04055977169966