Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

MABC276 Anti-BAG3 Antibody, clone AC-2

Anti-BAG3 Antibody, clone AC-2 detects level of BAG3 & has been published & validated for use in Western Blotting.

Anti-BAG3 Antibody, clone AC-2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Chaperones Gene Symbol: BAG3, BIS UniProt Number: O95817
MABC276
100 µL  
Purchase on Sigma-Aldrich

Special Offers

Overview

Replacement Information

Special Offers

100% Performance Guaranteed

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABC276
DescriptionAnti-BAG3 Antibody, clone AC-2
Alternate Names
  • BAG family molecular chaperone regulator 3
  • Bcl-2-associated athanogene 3
  • Bcl-2-binding protein Bis
  • Docking protein CAIR-1
Background InformationBcl2-associated athanogene 3 (BAG3), also known as CAIR-1 or Bis, belongs to a family of six evolutionarily conserved co-chaperone proteins that contain a characteristic C-terminal BAG domain. In most cell types, BAG3 is localized to the cytoplasm, where it regulates the heat shock protein 70 chaperone. BAG3 is activated in response to stressful stimuli, and plays a critical role in modulating multiple cellular processes, including apoptosis, autophagy, embryonic development, and actin rearrangement. Abnormal expression of BAG3 results cardiomyopathy dilated type 1HH.
References
Product Information
FormatPurified
Control
  • HeLa cell lysate
PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-BAG3 Antibody, clone AC-2 detects level of BAG3 & has been published & validated for use in Western Blotting.
Key Applications
  • Western Blotting
Application NotesImmunoprecipitation Analysis: A 1:500 dilution from a representative lot detected BAG3 IP'd from 500 µg of HeLa lysate.
Biological Information
ImmunogenMAP peptide corresponding to human BAG3.
CloneAC-2
HostMouse
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • BAG3
  • BIS
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~62-80 kDa observed. The calculated molecular weight of this protein is 62 kDa, but can run as high as 80 kDa due to PTM.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: A 1:1000 dilution of this antibody detected BAG3 in 10 µg of HeLa cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABC276 04053252599996

Documentation

Anti-BAG3 Antibody, clone AC-2 SDS

Title

Safety Data Sheet (SDS) 

Anti-BAG3 Antibody, clone AC-2 Certificates of Analysis

TitleLot Number
Anti-BAG3, clone AC-2 3077987
Anti-BAG3, clone AC-2 - 2517368 2517368
Anti-BAG3, clone AC-2 - 3212813 3212813
Anti-BAG3, clone AC-2 - 3856162 3856162
Anti-BAG3, clone AC-2 - 3888749 3888749
Anti-BAG3, clone AC-2 - Q2057901 Q2057901
Anti-BAG3, clone AC-2 -2625887 2625887
Anti-BAG3, clone AC-2 -2809287 2809287
Anti-BAG3, clone AC-2 Monoclonal Antibody 2949176