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647925 Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem

Trichostatin A, Streptomyces sp., CAS 58880-19-6, is a cell-permeable, potent, reversible inhibitor of histone deacetylase (IC50 = 6, 38, and 6 nM for HDAC1, 4, and 6, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA, HDAC Inhibitor IX

Primary Target: histone deactylase
647925
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
58880-19-6C₁₇H₂₂N₂O₃

Products

Catalogue NumberPackaging Qty/Pack
647925-1MG Plastic ampoule 1 mg
Description
OverviewA potent and reversible, cell-permeable inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-transformed NIH/3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model. Down-regulates p57kip2 in Hep 3B cells. IC50 = 6 nM for HDAC1; 38 nM for HDAC4, and 8.6 nM for HDAC6A. 10 mM (500 µg/165 µl) solution of Trichostatin A, Streptomyces sp. (Cat. No. 647926) in DMSO is also available.
Catalogue Number647925
Brand Family Calbiochem®
Synonyms4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA, HDAC Inhibitor IX
References
ReferencesFurumai, R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 87.
Gray, S.G. and Ekstrom, T.J. 1998. Biochem. Biophys. Res. Commun. 245, 423.
Takahashi, I., et al. 1996. J. Antibiot. 49, 453.
Taunton, J., et al. 1996. Science 272, 408.
Futamura, M., et al. 1995. Oncogene 10, 1119.
Hoshikawa, Y., et al. 1994. Exp. Cell Res. 214, 189.
Product Information
CAS number58880-19-6
ATP CompetitiveN
FormOff-white lyophilized solid
Hill FormulaC₁₇H₂₂N₂O₃
Chemical formulaC₁₇H₂₂N₂O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationTrichostatin A, Streptomyces sp., CAS 58880-19-6, is a cell-permeable, potent, reversible inhibitor of histone deacetylase (IC50 = 6, 38, and 6 nM for HDAC1, 4, and 6, respectively).
Biological Information
Primary Targethistone deactylase
Primary Target IC<sub>50</sub>73 nM inhibiting IL-2 gene expressionin Jurkat cells
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSMI5215000
Safety Information
R PhraseR: 20/21/22-36/37/38-43

Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
May cause sensitization by skin contact.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). Following reconstitution in ethanol, refrigerate (4°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
647925-1MG 07790788052003

Documentation

Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem Certificates of Analysis

TitleLot Number
647925

References

Reference overview
Furumai, R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 87.
Gray, S.G. and Ekstrom, T.J. 1998. Biochem. Biophys. Res. Commun. 245, 423.
Takahashi, I., et al. 1996. J. Antibiot. 49, 453.
Taunton, J., et al. 1996. Science 272, 408.
Futamura, M., et al. 1995. Oncogene 10, 1119.
Hoshikawa, Y., et al. 1994. Exp. Cell Res. 214, 189.

Brochure

Title
Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling

Technical Info

Title
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics

Citations

Title
  • Qiou Wei, W. Keith Miskimins and Robin Miskimins. (2005) Stage-specific expression of myelin basic protein in oligodendrocytes involves NKX2.2-mediated repression that is relieved by the Sp1 transcription factor. Journal of Biological Chemistry 280, 16284-16294.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision04-April-2016 JSW
    Synonyms4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA, HDAC Inhibitor IX
    DescriptionA potent and reversible inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-tranformed NIH 3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model. IC50 = 6 nM for HDAC1; 38 nM for HDAC4, and 8.6 nM for HDAC6A.
    FormOff-white lyophilized solid
    CAS number58880-19-6
    RTECSMI5215000
    Chemical formulaC₁₇H₂₂N₂O₃
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityDMSO (20 mg/ml), ethanol (1 mg/ml), or methanol
    Storage -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). Following reconstitution in ethanol, refrigerate (4°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at 4°C.
    Toxicity Harmful
    ReferencesFurumai, R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 87.
    Gray, S.G. and Ekstrom, T.J. 1998. Biochem. Biophys. Res. Commun. 245, 423.
    Takahashi, I., et al. 1996. J. Antibiot. 49, 453.
    Taunton, J., et al. 1996. Science 272, 408.
    Futamura, M., et al. 1995. Oncogene 10, 1119.
    Hoshikawa, Y., et al. 1994. Exp. Cell Res. 214, 189.
    Citation
  • Qiou Wei, W. Keith Miskimins and Robin Miskimins. (2005) Stage-specific expression of myelin basic protein in oligodendrocytes involves NKX2.2-mediated repression that is relieved by the Sp1 transcription factor. Journal of Biological Chemistry 280, 16284-16294.
    		•