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567750 Splitomicin - CAS 5690-03-9 - Calbiochem

A cell-permeable lactone derived from β-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC₅₀ = 60 µM).

Splitomicin - CAS 5690-03-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one

Primary Target: NAD+-dependent histone deacetylase activity of Sir2 protein
567750
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
5690-03-9C₁₃H₁₀O₂

Products

Catalogue NumberPackaging Qty/Pack
567750-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable lactone derived from β-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC50 = 60 µM). It creates a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.
Catalogue Number567750
Brand Family Calbiochem®
Synonyms1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
References
ReferencesBedalov, A., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 15113.
Product Information
CAS number5690-03-9
ATP CompetitiveN
FormOff-white powder
Hill FormulaC₁₃H₁₀O₂
Chemical formulaC₁₃H₁₀O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNAD+-dependent histone deacetylase activity of Sir2 protein
Primary Target IC<sub>50</sub>60 µM against NAD+-dependent histone deacetylase activity of Sir2 protein
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
567750-5MG 04055977190946

Documentation

Splitomicin - CAS 5690-03-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Splitomicin - CAS 5690-03-9 - Calbiochem Certificates of Analysis

TitleLot Number
567750

References

Reference overview
Bedalov, A., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 15113.

Brochure

Title
Overnight Express Autoinduction Systems

Technical Info

Title
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-September-2008 RFH
Synonyms1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
DescriptionA cell-permeable and selective inhibitor of NAD+-dependent deacetylase activity of Sir2 protein (IC50 = 60 µM). Creates a phenocopy of the sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Reported to act by either altering or blocking access to the acetylated histone-binding pocket.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number5690-03-9
Chemical formulaC₁₃H₁₀O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesBedalov, A., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 15113.