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565850 Shikonin - CAS 517-89-5 - Calbiochem

A naphthoquinone found in the Chinese herb Shiunko.

Shikonin - CAS 517-89-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Pyruvate Kinase Inhibitor II

Primary Target: TNF-α-induced and B-16 melanoma-induced angiogenesis
565850
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
517-89-5C₁₆H₁₆O₅

Products

Catalogue NumberPackaging Qty/Pack
565850-10MG Plastic ampoule 10 mg
Description
OverviewA naphthoquinone found in the Chinese herb Shiunko. Possesses significant antibacterial, anti-inflammatory, and antitumor activities. Inhibits TNF-α-induced and B-16 melanoma-induced angiogenesis in mice. Blocks the expression of integrin αvβ3 and inhibits endothelial cell proliferation and migration in vitro. Also induces apoptosis in HL60 human promyelocytic leukemia cell line.
Catalogue Number565850
Brand Family Calbiochem®
SynonymsPyruvate Kinase Inhibitor II
References
ReferencesChen, J., et al. 2011. Oncogene 30, 4297.
Li, H., et al. 1999. Phytother. Res. 13, 236.
Yoon, Y., et al. 1999. Planta Med. 65, 532.
Hisa, T., et al. 1998. Anticancer Res. 18, 783.
Product Information
CAS number517-89-5
ATP CompetitiveN
FormRed solid
Hill FormulaC₁₆H₁₆O₅
Chemical formulaC₁₆H₁₆O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetTNF-α-induced and B-16 melanoma-induced angiogenesis
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSQL8000200
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
565850-10MG 04055977191943

Documentation

Shikonin - CAS 517-89-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Shikonin - CAS 517-89-5 - Calbiochem Certificates of Analysis

TitleLot Number
565850

References

Reference overview
Chen, J., et al. 2011. Oncogene 30, 4297.
Li, H., et al. 1999. Phytother. Res. 13, 236.
Yoon, Y., et al. 1999. Planta Med. 65, 532.
Hisa, T., et al. 1998. Anticancer Res. 18, 783.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-December-2018 JSW
SynonymsPyruvate Kinase Inhibitor II
DescriptionA naphthoquinone found in the Chinese herb Lithospermum erythrorhizon. Possesses significant antibacterial, anti-inflammatory and antitumor activities. Inhibits TNF-α and B-16 melanoma-induced angiogenesis in mice. Blocks the expression of integrin αVβ3 and inhibits endothelial cells proliferation and migration in vitro. Also induces apoptosis in HL60 human promyelocytic leukemia cell line. Selectively blocks PKM2 (IC50 <1 µM) over PKM1 and PKL activities (IC50 in the range of 10-20 µM), and inhibits cancer cell glycolysis.
FormRed solid
CAS number517-89-5
RTECSQL8000200
Chemical formulaC₁₆H₁₆O₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesChen, J., et al. 2011. Oncogene 30, 4297.
Li, H., et al. 1999. Phytother. Res. 13, 236.
Yoon, Y., et al. 1999. Planta Med. 65, 532.
Hisa, T., et al. 1998. Anticancer Res. 18, 783.