Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

512732 Parthenolide, Tanacetum parthenium - CAS 20554-84-1 - Calbiochem

A cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages
512732
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
20554-84-1C₁₅H₂₀O₃

Products

Catalogue NumberPackaging Qty/Pack
512732-50MG Plastic ampoule 50 mg
Description
OverviewA cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.
Catalogue Number512732
Brand Family Calbiochem®
References
ReferencesWong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375.
Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.
Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.
Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.
Product Information
CAS number20554-84-1
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₅H₂₀O₃
Chemical formulaC₁₅H₂₀O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetthe expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSLY4220000
Safety Information
R PhraseR: 20/21/22-40-42/43

Harmful by inhalation, in contact with skin and if swallowed.
Limited evidence of a carcinogenic effect.
May cause sensitization by inhalation and skin contact.
S PhraseS: 22-36

Do not breathe dust.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
512732-50MG 04055977272079

Documentation

Parthenolide, Tanacetum parthenium - CAS 20554-84-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Parthenolide, Tanacetum parthenium - CAS 20554-84-1 - Calbiochem Certificates of Analysis

TitleLot Number
512732

References

Reference overview
Wong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375.
Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.
Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.
Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-August-2021 JSW
DescriptionA sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.
FormWhite solid
CAS number20554-84-1
RTECSLY4220000
Chemical formulaC₁₅H₂₀O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml) or ethanol (20 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
ReferencesWong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375.
Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.
Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.
Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.