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527450 PKR Inhibitor - CAS 608512-97-6 - Calbiochem

PKR Inhibitor, CAS 608512-97-6, is a potent, ATP-binding site directed PKR inhibitor that blocks RNA-induced PKR autophosphorylation (IC50 = 210 nM). Rescue PKR-dependent translation block.

PKR Inhibitor - CAS 608512-97-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PKRi, Double-stranded RNA-dependent Protein Kinase Inhibitor, C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I

Primary Target: PKR
527450
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
608512-97-6C₁₃H₈N₄OS

Products

Catalogue NumberPackaging Qty/Pack
527450-5MG Glass bottle 5 mg
Description
OverviewAn imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC50 = 210 nM) and rescue PKR-dependent translation block (IC50 = 100 nM). Inactive control is also available (Cat. No. 527455). Shown to increase the late phase of long-lasting synaptic potentiation, and enhance long-term memory in mice. Also available as a 50 mM solution in DMSO (Cat. No. 527451).
Catalogue Number527450
Brand Family Calbiochem®
SynonymsPKRi, Double-stranded RNA-dependent Protein Kinase Inhibitor, C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I
References
ReferencesZhu, P.J., et al. 2011. Cell 147, 1384.
Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.
Product Information
CAS number608512-97-6
ATP CompetitiveN
FormOrange to orange brown solid
Hill FormulaC₁₃H₈N₄OS
Chemical formulaC₁₃H₈N₄OS
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationPKR Inhibitor, CAS 608512-97-6, is a potent, ATP-binding site directed PKR inhibitor that blocks RNA-induced PKR autophosphorylation (IC50 = 210 nM). Rescue PKR-dependent translation block.
Biological Information
Primary TargetPKR
Primary Target IC<sub>50</sub>210 nM inhibiting RNA-induced PKR autophosphorylation and 100 nM in rescuing PKR-dependent translation block
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
527450-5MG 07790788055615

Documentation

PKR Inhibitor - CAS 608512-97-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PKR Inhibitor - CAS 608512-97-6 - Calbiochem Certificates of Analysis

TitleLot Number
527450

References

Reference overview
Zhu, P.J., et al. 2011. Cell 147, 1384.
Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-April-2018 JSW
SynonymsPKRi, Double-stranded RNA-dependent Protein Kinase Inhibitor, C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I
DescriptionAn imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC50 = 210 nM) and rescue PKR-dependent translation block (IC50 = 100 nM). Shown to increase the late phase of long-lasting synaptic potentiation, and enhance long-term memory in mice. Inactive control is also available (Cat. No. 527455).
FormOrange to orange brown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number608512-97-6
Chemical formulaC₁₃H₈N₄OS
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesZhu, P.J., et al. 2011. Cell 147, 1384.
Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.