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482200 Nimodipine - CAS 66085-59-4 - Calbiochem

An L-type Ca2+ channel blocker.

Nimodipine - CAS 66085-59-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,4-Dihydro-2,6-dimethyl-4-(3ʹ-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl Ester

Primary Target: L-type Ca2+ channel blocker
482200
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
66085-59-4C₂₁H₂₆N₂O₇

Products

Catalogue NumberPackaging Qty/Pack
482200-25MG Plastic ampoule 25 mg
Description
OverviewAn L-type Ca2+ channel blocker. Enhances memory in old or brain-damaged animals. Ameliorates experimental diabetic neuropathy in streptozotocin-induced diabetic rats. Also reported to block TNF-α and LPS-induced iNOS activity (IC50 = 36 pM) in mouse astroglial cells.
Catalogue Number482200
Brand Family Calbiochem®
Synonyms1,4-Dihydro-2,6-dimethyl-4-(3ʹ-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl Ester
References
ReferencesZhu, D., et al. 1999. Life. Sci. 65, PL 221.
Marchetti, C. and Usai, C. 1996. Neurosci. Lett. 207, 77.
Kappelle, A.C., et al. 1994. Br. J. Pharmacol. 111, 887.
Weiss, J.H., et al. 1994. J. Neurochem. 62, 372.
Kappelle, A.C., et al. 1993. Br. J. Pharmacol. 108, 780.
Product Information
CAS number66085-59-4
ATP CompetitiveN
FormYellow solid
Hill FormulaC₂₁H₂₆N₂O₇
Chemical formulaC₂₁H₂₆N₂O₇
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetL-type Ca2+ channel blocker
Primary Target IC<sub>50</sub>36 pM blocking TNF-α and LPS-induced iNOS activity in mouse astroglial cells
Purity>98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSUS7975500
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
482200-25MG 04055977183498

Documentation

Nimodipine - CAS 66085-59-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Nimodipine - CAS 66085-59-4 - Calbiochem Certificates of Analysis

TitleLot Number
482200

References

Reference overview
Zhu, D., et al. 1999. Life. Sci. 65, PL 221.
Marchetti, C. and Usai, C. 1996. Neurosci. Lett. 207, 77.
Kappelle, A.C., et al. 1994. Br. J. Pharmacol. 111, 887.
Weiss, J.H., et al. 1994. J. Neurochem. 62, 372.
Kappelle, A.C., et al. 1993. Br. J. Pharmacol. 108, 780.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-July-2023 JSW
Synonyms1,4-Dihydro-2,6-dimethyl-4-(3ʹ-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl Ester
DescriptionAn L-type Ca2+ channel blocker. Enhances memory in old or brain-damaged animals. Ameliorates experimental diabetic neuropathy in streptozotocin-induced diabetic rats.
FormYellow solid
CAS number66085-59-4
RTECSUS7975500
Chemical formulaC₂₁H₂₆N₂O₇
Structure formulaStructure formula
Purity>98% by HPLC
SolubilityDMSO (25 mg/ml) or methanol
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
Merck USA index14, 6551
ReferencesZhu, D., et al. 1999. Life. Sci. 65, PL 221.
Marchetti, C. and Usai, C. 1996. Neurosci. Lett. 207, 77.
Kappelle, A.C., et al. 1994. Br. J. Pharmacol. 111, 887.
Weiss, J.H., et al. 1994. J. Neurochem. 62, 372.
Kappelle, A.C., et al. 1993. Br. J. Pharmacol. 108, 780.