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20-221 NAD Cofactor

20-221
10 mg  
Purchase on Sigma-Aldrich

Overview

Key Spec Table

Key Applications
HDAC
Description
Catalogue Number20-221
Brand Family Upstate
Trade Name
  • Upstate
DescriptionNAD Cofactor
OverviewDescription: β-nicotinamide adenine dinucleotide hydrate

FW: 663.4

Use: Can be used as a cofactor in reactions with NAD-dependent histone deacetylase enzymes.
Product Information
Presentationlyophilized powder
Quality LevelMQ100
Applications
ApplicationCan be used as a cofactor in reactions with NAD-dependent histone deacetylase enzymes.
Key Applications
  • Histone Deacetylase Assay (HDAC)
Biological Information
Entrez Gene Number
Entrez Gene SummaryIsocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase.
Gene Symbol
  • IDH3A
  • NAD
UniProt Number
UniProt SummaryCOFACTOR: Binds 1 magnesium or manganese ion per subunit (By similarity).
SIZE: 366 amino acids; 39592 Da
SUBUNIT: Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1 (By similarity).
SUBCELLULAR LOCATION: Mitochondrion.
SIMILARITY: SwissProt: P50213 ## Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions1 year at room temperature
Packaging Information
Material Size10 mg
Global Trade Item Number
Catalogue Number GTIN
20-221 04053252322129