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681660 N-WASP-Inhibitor, 187-1 - CAS 380488-27-7 - Calbiochem

The N-WASP-Inhibitor, 187-1 controls the biological activity of neural Wiskott Aldrich syndrome protein (N-WASP). This small molecule/inhibitor is primarily used for Cell Structure applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: cyclo(LKDFDPDFLFDPLQ)₂

Primary Target: Neural Wiskott Aldrich syndrome protein (N-WASP)
681660
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
380488-27-7C₉₆H₁₂₂N₁₈O₁₆

Products

Catalogue NumberPackaging Qty/Pack
681660-1MG Plastic ampoule 1 mg
Description
OverviewA 14-amino acid cyclic peptide that potently blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-induced actin assembly in Xenopus egg cytoplasmic extract (IC50 ~ 2 µM). Shown to directly bind to neural Wiskott Aldrich syndrome protein (N-WASP) with high-affinity, and prevent the activation of actin-related protein 2/3 (Arp2/3) complex by inhibiting the interaction between N-WASP and Arp2/3.
Catalogue Number681660
Brand Family Calbiochem®
Synonymscyclo(LKDFDPDFLFDPLQ)₂
References
ReferencesPeterson, J.R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10624.
Suetsugu, S., et al. 2001. J. Biol. Chem. 276, 33175.
Product Information
CAS number380488-27-7
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₉₆H₁₂₂N₁₈O₁₆
Chemical formulaC₉₆H₁₂₂N₁₈O₁₆
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetNeural Wiskott Aldrich syndrome protein (N-WASP)
Primary Target IC<sub>50</sub>~ 2 µM blocking phosphatidylinositol 4,5-bisphosphate (PIP2)-induced actin assembly in Xenopus egg cytoplasmic extract
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide Sequencecyclo(LLys-DPhe-DPro-DPhe-LPhe-DPro-LGln)₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
681660-1MG 04055977260212

Documentation

N-WASP-Inhibitor, 187-1 - CAS 380488-27-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

N-WASP-Inhibitor, 187-1 - CAS 380488-27-7 - Calbiochem Certificates of Analysis

TitleLot Number
681660

References

Reference overview
Peterson, J.R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10624.
Suetsugu, S., et al. 2001. J. Biol. Chem. 276, 33175.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-September-2008 RFH
Synonymscyclo(LKDFDPDFLFDPLQ)₂
DescriptionA 14-amino acid cyclic peptide that potently blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-induced actin assembly in Xenopus egg cytoplasmic extract (IC50 ~2 µM). Shown to directly bind to neural Wiskott Aldrich syndrome protein (N-WASP) with high-affinity, and allosterically stabilize the autoinhibited conformation of N-WASP. It prevents the activation of actin-related protein 2/3 (Arp2/3) complex by blocking the interaction between N-WASP and Arp2/3.
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
CAS number380488-27-7
Chemical formulaC₉₆H₁₂₂N₁₈O₁₆
Peptide Sequencecyclo(LLys-DPhe-DPro-DPhe-LPhe-DPro-LGln)₂
Purity≥95% by HPLC
SolubilityDMSO (1 mg/ml) or Acetic Acid (5%)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesPeterson, J.R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10624.
Suetsugu, S., et al. 2001. J. Biol. Chem. 276, 33175.