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444274 MMP-2/MMP-9 Inhibitor IV - CAS 292605-14-2 - Calbiochem

The MMP-2/MMP-9 Inhibitor IV, also referenced under CAS 292605-14-2, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: SB-3CT

Primary Target: MMP-2
444274
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
292605-14-2C₁₅H₁₄O₃S₂

Products

Catalogue NumberPackaging Qty/Pack
444274-500UG Plastic ampoule 500 μg
Description
OverviewA potent, selective, slow-binding and mechanism-based inhibitor of human gelatinases, MMP-2 (Ki = 13.9 nM), and MMP-9 (Ki = 600 nM). This inhibitor appears to behave similarly to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Also exhibits a covalent mechanism-based behavior in inhibition of these enzymes. Binds directly to the catalytic zinc ion on MMP-2.
Catalogue Number444274
Brand Family Calbiochem®
SynonymsSB-3CT
References
ReferencesKrüger, A., et al. 2005. Cancer Res. 65, 3523.
Kleinfeld, O., et al. 2001. J. Biol. Chem. 276, 17125.
Brown, S., et al. 2000. J. Am. Chem. Soc. 122, 6799.
Product Information
CAS number292605-14-2
ATP CompetitiveN
DeclarationSold under license of U.S. Patent 6,703,415.
FormOff-white solid
Hill FormulaC₁₅H₁₄O₃S₂
Chemical formulaC₁₅H₁₄O₃S₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMMP-2
Primary Target K<sub>i</sub>13.9 nM
Purity≥ 95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
444274-500UG 04055977186581

Documentation

MMP-2/MMP-9 Inhibitor IV - CAS 292605-14-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MMP-2/MMP-9 Inhibitor IV - CAS 292605-14-2 - Calbiochem Certificates of Analysis

TitleLot Number
444274

References

Reference overview
Krüger, A., et al. 2005. Cancer Res. 65, 3523.
Kleinfeld, O., et al. 2001. J. Biol. Chem. 276, 17125.
Brown, S., et al. 2000. J. Am. Chem. Soc. 122, 6799.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-April-2019 JSW
SynonymsSB-3CT
DescriptionA potent, selective, slow-binding and mechanism-based inhibitor of human gelatinases, MMP-2 (Ki = 13.9 nM) and MMP-9 (Ki = 600 nM). It also exhibits a covalent mechanism based behavior in inhibition of these enzymes. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Shown to directly bind to the zinc in the catalytic site of MMP-2. Does not affect the activities of MMP-1 (Ki = 206 µM) MMP-3 (Ki = 15 µM), or MMP-7 (Ki = 96 µM).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number292605-14-2
Chemical formulaC₁₅H₁₄O₃S₂
Structure formulaStructure formula
Purity≥ 95% by HPLC
SolubilityDMSO (>20 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesKrüger, A., et al. 2005. Cancer Res. 65, 3523.
Kleinfeld, O., et al. 2001. J. Biol. Chem. 276, 17125.
Brown, S., et al. 2000. J. Am. Chem. Soc. 122, 6799.