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443300 MCI-186 - CAS 89-25-8 - Calbiochem

A free radical scavenger and antioxidant that reduces post-ischemic brain injury.

MCI-186 - CAS 89-25-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Methyl-1-phenyl-2-pyrazolin-5-one, PMP, Edaravone

443300
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
89-25-8C₁₀H₁₀N₂O

Products

Catalogue NumberPackaging Qty/Pack
443300-500MG Plastic ampoule 500 mg
Description
OverviewA free radical scavenger and antioxidant that reduces post-ischemic brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC50 = 15 µM). Inhibits mitochondrial permeability transition pore.
Catalogue Number443300
Brand Family Calbiochem®
Synonyms3-Methyl-1-phenyl-2-pyrazolin-5-one, PMP, Edaravone
References
ReferencesKatare, R. G., et al. 2003. Am. J. Physiol. 285, H2171.
Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281, 921.
Yamamoto, Y., et al. 1996. Redox. Report 2, 333.
Watanabe, T., et al. 1994. J. Pharmacol. Exp. Ther. 268, 1597.
Nishi, H., et al. 1989. Stroke 20, 1236.
Product Information
CAS number89-25-8
ATP CompetitiveN
FormCream-colored solid
Hill FormulaC₁₀H₁₀N₂O
Chemical formulaC₁₀H₁₀N₂O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetA free radical scavenger and antioxidant
Primary Target IC<sub>50</sub>15 µM inhibiting iron-dependent peroxidation in rat brain homogenates
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSUQ9625000
Safety Information
R PhraseR: 22-36/37/38-43

Harmful if swallowed.
Irritating to eyes, respiratory system and skin.
May cause sensitization by skin contact.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
443300-500MG 04055977205350

Documentation

MCI-186 - CAS 89-25-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MCI-186 - CAS 89-25-8 - Calbiochem Certificates of Analysis

TitleLot Number
443300

References

Reference overview
Katare, R. G., et al. 2003. Am. J. Physiol. 285, H2171.
Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281, 921.
Yamamoto, Y., et al. 1996. Redox. Report 2, 333.
Watanabe, T., et al. 1994. J. Pharmacol. Exp. Ther. 268, 1597.
Nishi, H., et al. 1989. Stroke 20, 1236.

Brochure

Title
Pathways and Biomarkers of Oxidative Stress
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-August-2008 JSW
Synonyms3-Methyl-1-phenyl-2-pyrazolin-5-one, PMP, Edaravone
DescriptionA free radical scavenger and antioxidant that reduces post-ischemie brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC50 = 15 µM). Inhibits mitochondrial permeability transition pore.
FormCream-colored solid
Intert gas (Yes/No) Packaged under inert gas
CAS number89-25-8
RTECSUQ9625000
Chemical formulaC₁₀H₁₀N₂O
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
Merck USA index14, 6713
ReferencesKatare, R. G., et al. 2003. Am. J. Physiol. 285, H2171.
Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281, 921.
Yamamoto, Y., et al. 1996. Redox. Report 2, 333.
Watanabe, T., et al. 1994. J. Pharmacol. Exp. Ther. 268, 1597.
Nishi, H., et al. 1989. Stroke 20, 1236.