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01-172 Interferon-gamma (IFNγ)

This Interferon-gamma (IFNγ) protein is available in a 100 µg format.

Interferon-gamma (IFNγ) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Cell Culture UniProt Number: P01579 Entrez Gene Number: NM_000619.2
01-172
100 µg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Key ApplicationsSpeciesSource
CULTHuman Recombinant Human Interferon-gamma
Description
Catalogue Number01-172
Brand Family Upstate
Trade Name
  • Upstate
DescriptionInterferon-gamma (IFNγ)
References
Product Information
PresentationLyophilized from PBS, pH 7.4
Applications
ApplicationThis Interferon-gamma (IFNγ) protein is available in a 100 µg format.
Key Applications
  • Cell Culture
Biological Information
SourceRecombinant Human Interferon-gamma
Entrez Gene Number
Gene Symbol
  • IFNG
  • IFN-gamma
  • IFI
  • IFG
Purification MethodSterilized through a 0.2 micron membrane filter
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P01579 # Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
SIZE: 166 amino acids; 19348 Da
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Released primarily from activated T lymphocytes.
PTM: Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
DISEASE: SwissProt: P01579 # In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
SIMILARITY: SwissProt: P01579 ## Belongs to the type II (or gamma) interferon family.
Stem Cell Type
  • Mesenchymal Stem Cells
  • Hematopoietic Stem Cells
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated in a biological activity assay.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
01-172 04053252338274

Documentation

Interferon-gamma (IFNγ) Certificates of Analysis

TitleLot Number
IFN-g (Interferon-g) (recombinant protein expressed in E. coli) - 1958108 1958108
IFN-g (Interferon-g) - DAM1570813 DAM1570813
IFN-g (Interferon-g) - DAM1780346 DAM1780346
IFN-g (Interferon-g) - JBC1863396 JBC1863396
IFN-y (Interferon-y) -
IFN-y (Interferon-y) - DAM1557437 DAM1557437
IFNgamma; - 0609040828 0609040828
IFNgamma; - 15871 15871
IFNgamma; - 16597 16597
IFNgamma; - 18659 18659
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References

Reference overviewApplicationPub Med ID
Tumor necrosis factor alpha (TNFalpha) promotes growth of virulent Mycobacterium tuberculosis in human monocytes iron-mediated growth suppression is correlated with decreased release of TNFalpha from iron-treated infected monocytes
Byrd, T. F.
J Clin Invest, 99:2518-29 (1997)  1997

Cell Culture9153296 9153296
Co-regulation and physical association of the 67-kDa monomeric laminin receptor and the alpha6beta4 integrin
Ardini, E., et al
J Biol Chem, 272:2342-5 (1997)  1997

Cell Culture8999943 8999943
The molecular cell biology of interferon-gamma and its receptor.
Farrar, M A and Schreiber, R D
Annu. Rev. Immunol., 11: 571-611 (1993)  1993

Show Abstract 		8476573 8476573

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