557404 Sigma-AldrichInSolution™ RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem
The InSolution™ RNA Polymerase III Inhibitor, also referenced under CAS 577784-91-9, controls the biological activity of RNA Polymerase III. This small molecule/inhibitor is primarily used for Cell St
More>> The InSolution™ RNA Polymerase III Inhibitor, also referenced under CAS 577784-91-9, controls the biological activity of RNA Polymerase III. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide, N-(1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl))-2-chlorobenzenesulfonamide
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 577784-91-9 | C₁₉H₁₅Cl₂N₃O₂S₂ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 557404-5MG | Glass bottle | 5 mg |
| Description | |
|---|---|
| Overview | A cell-permeable inhibitor of RNA polymerase III (RNA Pol III) (IC50 = 27 µM for human RNA Pol III and 32 µM for Saccharomyces cerevisiae RNA Pol III). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. The solid form of this compound (Cat. No. 557403) is also available. |
| Catalogue Number | 557404 |
| Brand Family | Calbiochem® |
| Synonyms | 2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide, N-(1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl))-2-chlorobenzenesulfonamide |
| References | |
|---|---|
| References | Wu, L., et al. 2003. Euk. Cell 2, 256. |
| Product Information | |
|---|---|
| CAS number | 577784-91-9 |
| Form | Liquid |
| Formulation | A 25 mM (5 mg/442 µL) solution of RNA Polymerase III Inhibitor (Cat. No. 557403) in DMSO. |
| Hill Formula | C₁₉H₁₅Cl₂N₃O₂S₂ |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | RNA Polymerase III |
| Primary Target IC<sub>50</sub> | 27 µ |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 557404-5MG | 04055977268065 |