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401487 IKK-2 Inhibitor VIII - CAS 406208-42-2 - Calbiochem

401487
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Overview

Key Spec Table

CAS #Empirical Formula
406208-42-2C₂₁H₂₄N₄O₂

Products

Catalogue NumberPackaging Qty/Pack
401487-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable piperidinyl-pyridine compound that acts as a selective inhibitor of IKK-2 activity (IC50 = 8.5 and 250 nM for IKK-2 and IKK-1, respectively) with little effect towards IKK-3, Syk, and MKK4 (IC50 >20 µM). Exhibits good aqueous solubility (0.12 mg/ml in pH 7.4 isotonic buffer) and potent activity in various cellular assays in vitro (IC50 <150 nM). Shown to be orally bioavailable both in rats and mice (BA = 60% and 16%, respectively) and effectively inhibit arachidonic acid-induced swelling in a murine ear edema model in vivo.
Catalogue Number401487
Brand Family Calbiochem®
Synonyms2-Amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-(4-piperidinyl)-3-pyridinecarbonitrile, ACHP
References
ReferencesMurata, T., et al. 2004. Bioorg. Med. Chem. Lett. 14, 4019.
Product Information
CAS number406208-42-2
ATP CompetitiveN
FormYellow solid
Hill FormulaC₂₁H₂₄N₄O₂
Chemical formulaC₂₁H₂₄N₄O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetIKK-2
Primary Target IC<sub>50</sub>8.5 and 250 nM for IKK-2 and IKK-1, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
401487-1MG 04055977212044