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505275 ICI 118551 Hydrochloride - CAS 72795-01-8 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms:  (±)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride

Primary Target: →2 adrenergic receptors
505275
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
72795-01-8C₁₇H₂₇NO₂ • HCl

Products

Catalogue NumberPackaging Qty/Pack
5052750001 Glass bottle 10 mg
Description
OverviewA highly selective antagonist for the β2 adrenergic receptors. Binds to the β2 subtype with at least 100 times greater affinity than β1 or β3, the two other known subtypes of the beta adrenoceptor. (Ki values are 1.2, 120 and 257 nM for β2, β1 and β3 receptors respectively).
Catalogue Number505275
Brand Family Calbiochem®
Synonyms (±)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride
References
ReferencesBilski, A., et al. 1983. J. Cardiovasc. Pharmacol. 5, 430.
Cook, S. et al. 1993. Br. J .Pharmacol. 109, 1140.
Ten Berge, R., et al. 1995. Eur. J. Pharmacol. 275, 199.
Strosberg, A., et al. 1996. TiPS 17, 373.
Product Information
CAS number72795-01-8
FormWhite solid
Hill FormulaC₁₇H₂₇NO₂ • HCl
Chemical formulaC₁₇H₂₇NO₂ • HCl
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target→2 adrenergic receptors
Primary Target K<sub>i</sub>1.2, 120 and 257 nM for →2, →1 and →3 receptors respectively.
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +15°C to +30°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5052750001 04055977263527

Documentation

ICI 118551 Hydrochloride - CAS 72795-01-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Bilski, A., et al. 1983. J. Cardiovasc. Pharmacol. 5, 430.
Cook, S. et al. 1993. Br. J .Pharmacol. 109, 1140.
Ten Berge, R., et al. 1995. Eur. J. Pharmacol. 275, 199.
Strosberg, A., et al. 1996. TiPS 17, 373.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-July-2019 JSW
Synonyms (±)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride
DescriptionA highly selective antagonist for the β2 adrenergic receptors. Binds to the β2 subtype with at least 100 times greater affinity than β1 or β3, the two other known subtypes of the beta adrenoceptor. (Ki values are 1.2, 120 and 257 nM for β2, β1 and β3 receptors respectively).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number72795-01-8
Chemical formulaC₁₇H₂₇NO₂ • HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBilski, A., et al. 1983. J. Cardiovasc. Pharmacol. 5, 430.
Cook, S. et al. 1993. Br. J .Pharmacol. 109, 1140.
Ten Berge, R., et al. 1995. Eur. J. Pharmacol. 275, 199.
Strosberg, A., et al. 1996. TiPS 17, 373.