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385880 Hsp25 Kinase Inhibitor - Calbiochem

The Hsp25 Kinase Inhibitor controls the biological activity of Hsp25 KInase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Hsp25 Kinase Inhibitor - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MAPKAP Kinase-2 Inhibitor, KKKALNRQLGVAA, MK2 Inhibitor

Primary Target: (Hsp25) kinase
385880
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₆₁H₁₁₃N₂₁O₁₆

Products

Catalogue NumberPackaging Qty/Pack
385880-1MG Plastic ampoule 1 mg
Description
OverviewA 13-residue, cell-permeable peptide that acts as a potent and selective inhibitor of mammalian heat-shock protein (Hsp25) kinase [also called mitogen-activated protein kinase-activated protein kinase-2 (MAPKAP kinase-2)]. Inhibition is competitive with respect to the substrate peptide (Ki = 8.1 µM) and non-competitive with respect to ATP (Ki = 134 µM).
Catalogue Number385880
Brand Family Calbiochem®
SynonymsMAPKAP Kinase-2 Inhibitor, KKKALNRQLGVAA, MK2 Inhibitor
References
ReferencesKatsoulidis, E., et al. 2005. Cancer Res. 65, 9029.
Hayess, K., and Benndorf, R. 1997. Biochem. Pharmacol. 53, 1239.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₆₁H₁₁₃N₂₁O₁₆
Chemical formulaC₆₁H₁₁₃N₂₁O₁₆
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary Target(Hsp25) kinase
Primary Target K<sub>i</sub>8.1 µM against (Hsp25) kinase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceH-Lys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
385880-1MG 04055977190311

Documentation

Hsp25 Kinase Inhibitor - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Hsp25 Kinase Inhibitor - Calbiochem Certificates of Analysis

TitleLot Number
385880

References

Reference overview
Katsoulidis, E., et al. 2005. Cancer Res. 65, 9029.
Hayess, K., and Benndorf, R. 1997. Biochem. Pharmacol. 53, 1239.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-March-2009 JSW
SynonymsMAPKAP Kinase-2 Inhibitor, KKKALNRQLGVAA, MK2 Inhibitor
DescriptionA 13-residue, cell-permeable peptide that acts as a potent and selective inhibitor of mammalian heat-shock protein (Hsp25) kinase. Inhibits Hsp25 kinase competitively with respect to the substrate peptide (Ki = 8.1 µM) and non-competitive with respect to ATP (Ki = 134 µM). [Hsp 25 kinase is also called mitogen-activated protein kinase-activated protein kinase-2 (MK2).]
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Chemical formulaC₆₁H₁₁₃N₂₁O₁₆
Peptide SequenceH-Lys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala-OH
Purity≥98% by HPLC
SolubilityDMSO or H₂O
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
Toxicity Standard Handling
ReferencesKatsoulidis, E., et al. 2005. Cancer Res. 65, 9029.
Hayess, K., and Benndorf, R. 1997. Biochem. Pharmacol. 53, 1239.