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508014 GR 127935 Hydrochloride - CAS 148642-42-6 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-HT1B/1D Serotonin Receptor Antagonist, GR 127935 Hydrochloride, GR-127935 hydrochloride, GR127935 hydrochloride

Primary Target: 5-HT1B/1D
508014
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
148642-42-6C₂₉H₃₁N₅O₃·HCl

Products

Catalogue NumberPackaging Qty/Pack
5080140001 Glass bottle 10 mg
Description
OverviewA selective 5-HT1B/1D receptor antagonist. Selectivity was found to be similar for B (pki = 9.2-9.8 )and D (pki = 8.6-9.1) receptor types. GR 127935 works well in vivo and was shown to block (+)-MDMA-induced hyperactivity in rats. It alters release of serotonin in the brain, as well as reducing drug-seeking behaviour in cocaine addicted rats. In transformed rat C5 glioma cells, this inhibitor blocked 5HT with an IC50 = 97 pM.
Catalogue Number508014
Brand Family Calbiochem®
Synonyms5-HT1B/1D Serotonin Receptor Antagonist, GR 127935 Hydrochloride, GR-127935 hydrochloride, GR127935 hydrochloride
References
ReferencesRex, A. et al. 2008. Pharmacology, Biochemistry, and Behavior. 88, 196.
Przegalinski, E. et al. 2008. Pharmacol. Rep. 60, 798.
Bannai, M. et al. 2007. Psychopharmacol. 93, 295.
McCreary A. C. et al. 1999. J. Pharmacol. Exp. Ther. 290, 965.
Pauwels, P. J. et al. 1996. J. Neurochem. 66, 65.
Skingle, M. et al. 1996. Behav.Brain Res. 73, 157.
Product Information
CAS number148642-42-6
FormOff-white solid
Hill FormulaC₂₉H₃₁N₅O₃·HCl
Chemical formulaC₂₉H₃₁N₅O₃·HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target5-HT1B/1D
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5080140001 04055977242744

Documentation

GR 127935 Hydrochloride - CAS 148642-42-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

GR 127935 Hydrochloride - CAS 148642-42-6 - Calbiochem Certificates of Analysis

TitleLot Number
508014

References

Reference overview
Rex, A. et al. 2008. Pharmacology, Biochemistry, and Behavior. 88, 196.
Przegalinski, E. et al. 2008. Pharmacol. Rep. 60, 798.
Bannai, M. et al. 2007. Psychopharmacol. 93, 295.
McCreary A. C. et al. 1999. J. Pharmacol. Exp. Ther. 290, 965.
Pauwels, P. J. et al. 1996. J. Neurochem. 66, 65.
Skingle, M. et al. 1996. Behav.Brain Res. 73, 157.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-September-2013 JSW
Synonyms5-HT1B/1D Serotonin Receptor Antagonist, GR 127935 Hydrochloride, GR-127935 hydrochloride, GR127935 hydrochloride
DescriptionA selective 5-HT1B/1D receptor antagonist. Selectivity was found to be similar for B (pki = 9.2-9.8 )and D (pki = 8.6-9.1) receptor types. GR 127935 works well in vivo and was shown to block (+)-MDMA-induced hyperactivity in rats. It alters release of serotonin in the brain, as well as reducing drug-seeking behaviour in cocaine addicted rats. In transformed rat C5 glioma cells, this inhibitor blocked 5HT with an IC50 = 97 pM.
FormOff-white solid
CAS number148642-42-6
Chemical formulaC₂₉H₃₁N₅O₃·HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesRex, A. et al. 2008. Pharmacology, Biochemistry, and Behavior. 88, 196.
Przegalinski, E. et al. 2008. Pharmacol. Rep. 60, 798.
Bannai, M. et al. 2007. Psychopharmacol. 93, 295.
McCreary A. C. et al. 1999. J. Pharmacol. Exp. Ther. 290, 965.
Pauwels, P. J. et al. 1996. J. Neurochem. 66, 65.
Skingle, M. et al. 1996. Behav.Brain Res. 73, 157.