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371721 GPR40 Agonist II - CAS 1206629-08-4 - Calbiochem

371721
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Overview

Key Spec Table

CAS #Empirical Formula
1206629-08-4C₁₆H₁₁Cl₂NO₂

Products

Catalogue NumberPackaging Qty/Pack
371721-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable alkynedihydrocinnamic acid that acts as a potent GPR40/FFA1 agonist (EC50 = 40.7 nM in inducing Ca2+ mobilization in hFFA1-expressing 1321N1 cells) with >100-fold selectivity over GPR43/FFA2, GPR41/FFA3, and a panel of 56 other receptors, ion channels, and transporters. Reported to enhance 12 mM glucose-induced insulin secretion from rat INS-1E β-cells (by 34% at 10 µM) and exhibit good aqueous solubility (199 µM in PBS at pH 7.4), as well as chemical and metabolic stability.
Catalogue Number371721
Brand Family Calbiochem®
Synonyms3-(4-((2,6-Dichloropyridin-4-yl)ethynyl)phenyl)propanoic acid, FFA1 Agonist II, Free Fatty Acid Receptor 1 Agonist II
References
ReferencesChristiansen, E., et al. 2011, J. Med. Chem. 54, 6691.
Product Information
CAS number1206629-08-4
FormOff-white powder
Hill FormulaC₁₆H₁₁Cl₂NO₂
Chemical formulaC₁₆H₁₁Cl₂NO₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥98% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C>
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
371721-10MG 04055977213249