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48-602MAG
Buffer Detection Kit for Magnetic Beads
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341310
Sigma-AldrichFABP4 Inhibitor - CAS 300657-03-8 - Calbiochem
The FABP4 Inhibitor, also referenced under CAS 300657-03-8, controls the biological activity of FABP4.
More>>The FABP4 Inhibitor, also referenced under CAS 300657-03-8, controls the biological activity of FABP4. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
A cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting its fatty acid-binding pocket (Ki = < 2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP's (Ki = 250 nM and 350 nM, respectively). Shown to effectively block foam cell transformation and the cellular expression of inflammatory mediators in aP2-positive, but not aP2-negative, THP-1 macrophage in vitro, as well as improve the glucose metabolism and insulin sensitivity in mice in vivo.
Catalogue Number
341310
Brand Family
Calbiochem®
Synonyms
adipocyte Fatty-Acid-Binding Protein Inhibitor, ((2ʹ-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)(1,1ʹ-biphenyl)-3-yl)oxy)-acetic acid, BMS309403, BMS-309403, BMS 309403
References
References
Furuhashi, M., et al. 2007. Nature447, 959. Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett.17, 3511.
Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Standard Handling
Storage
+2°C to +8°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas
Packaged under inert gas
Global Trade Item Number
Catalogue Number
GTIN
341310-5MG
04055977215656
Documentation
FABP4 Inhibitor - CAS 300657-03-8 - Calbiochem SDS
FABP4 Inhibitor - CAS 300657-03-8 - Calbiochem Certificates of Analysis
Title
Lot Number
341310
References
Reference overview
Furuhashi, M., et al. 2007. Nature447, 959. Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett.17, 3511.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
08-October-2008 JSW
Synonyms
adipocyte Fatty-Acid-Binding Protein Inhibitor, ((2ʹ-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)(1,1ʹ-biphenyl)-3-yl)oxy)-acetic acid, BMS309403, BMS-309403, BMS 309403
Description
A cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting its fatty acid-binding pocket (Ki = < 2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP's (Ki = 250 nM and 350 nM, respectively). Shown to effectively block foam cell transformation and the cellular expression of inflammatory mediators in aP2-positive, but not aP2-negative, THP-1 macrophage in vitro, as well as improve the glucose metabolism and insulin sensitivity in mice in vivo.
Form
White solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
300657-03-8
Chemical formula
C₃₁H₂₆N₂O₃
Structure formula
Purity
≥98% by HPLC
Solubility
DMSO (50 mg/ml), Methanol (50 mg/ml), or Ethanol (20 mg/ml)
Storage
Protect from light +2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity
Standard Handling
References
Furuhashi, M., et al. 2007. Nature447, 959. Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett.17, 3511.
