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324630 EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem

The racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor and adenosine deaminase.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: erythro-9-(2-Hydroxy-3-nonyl)adenine, HCl

Primary Target: PDE 2
324630
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Overview

Key Spec Table

CAS #Empirical Formula
51350-19-7C₁₄H₂₃N₅O · HCl

Products

Catalogue NumberPackaging Qty/Pack
324630-10MG Plastic ampoule 10 mg
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Description
OverviewThe racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor (IC50 = 0.8 and 2 µM against human and procine PDE II, respectively) and adenosine deaminase (Ki = 4 nM), while exhibiting little or much reduced potency toward PDE I/II/IV isozymes (IC50 >100 µM) of both human and porcine species. EHNA at 10 µM concentration is also reported to effectively and reversibly block the differentiation and maintain the pluripotency of hES (human embryonic stem) cell line SA121 in feeder-free cultures without exogenously added FGF for up to 30 passages in a manner independent of its known ADA and PDE inhibitory activities.
Catalogue Number324630
Brand Family Calbiochem®
Synonymserythro-9-(2-Hydroxy-3-nonyl)adenine, HCl
References
ReferencesBurton, P., et al. 2010. Biochem. J. in press.
Lorbar, M., et al. 1999. J. Mol. Cell. Cardiol. 31, 401.
Verde, I., et al. 1999. Br. J. Pharmacol. 127, 65.
Reynolds, A.J., et al. 1996. Brain Res. 798, 67.
Mery, P.F., et al. 1995. Mol. Pharmacol. 48, 121.
Podzuweit, T., et al. 1995. Cell. Signal. 7, 733.
Bessodes, M., et al. 1982. Biochem. Pharmacol. 31, 879.
Bouchard, P., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 1033.
Product Information
CAS number51350-19-7
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₄H₂₃N₅O · HCl
Chemical formulaC₁₄H₂₃N₅O · HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetPDE 2
Primary Target IC<sub>50</sub>0.8 and 2 µM against human and procine PDE II, respectively
Primary Target K<sub>i</sub>4 nM against adenosine deaminase
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
324630-10MG 04055977196733