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292505 Diethylamine NONOate/AM - CAS 213768-16-2 - Calbiochem

292505
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Overview

Key Spec Table

CAS #Empirical Formula
213768-16-2C₇H₁₅N₃O₄

Products

Catalogue NumberPackaging Qty/Pack
292505-1MG Plastic ampoule 1 mg
Description
OverviewAn esterase-sensitive and cell permeable, O2-acetoxymethylated diazeniumdiolate that acts as an intracellular nitric oxide (NO) donor (1.83 mol of NO/mol). Shown to induce apoptosis and to act as an antiproliferative agent in NO-sensitive human leukemia HL-60 (IC50 = 8.3 µM) and U937 (IC50 = 53 µM) cell lines. Also suppresses oxidized low-density lipoprotein-induced caspase-3 activation in bovine aortic endothelial cells. Exhibits enhanced stability in physiological buffers. May also be useful for temporal and spatial controlled NO availability.
Catalogue Number292505
Brand Family Calbiochem®
References
ReferencesKotamraju, S., et al. 2001. J. Biol. Chem. 276, 17316.
Saavedra, J.E., et al. 2000. J. Med. Chem. 43, 261.
Product Information
CAS number213768-16-2
ATP CompetitiveN
FormYellow liquid
Hill FormulaC₇H₁₅N₃O₄
Chemical formulaC₇H₁₅N₃O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetIntracellular nitric oxide (NO) donor
Primary Target IC<sub>50</sub>8.3 µM, 53 µM, acting as an antiproliferative agent in NO-sensitive human leukemia HL-60 and U937 cell lines, respectively
Purity≥95% by NMR
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 2 months at -20°C. Add to aqueous medium just prior to use.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
292505-1MG 04055977197945