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204883 Sigma-AldrichComplement C1-Esterase Inhibitor, Human

Complement C1-Esterase Inhibitor, Human, is a native, single-chain glycoprotein that is involved in regulation of complement, coagulation, fibrinolytic and contact systems of circulating plasma.

Complement C1-Esterase Inhibitor, Human MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet

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Overview

Products

Catalogue Number	Packaging	Qty/Pack
204883-1MG	Plastic ampoule	1 mg	Add To Favorites Add To Favorites Added To My Favorites

Description
Overview	Native, human C1-esterase. Single-chain glycoprotein present in normal human serum at 180 µg/ml. Involved in regulation of complement, coagulation, fibrinolytic and contact (kinin-forming) systems of circulating blood plasma. The only known inhibitor of activated C1r and C1s complement enzymes. The presence of either hereditary or acquired deficiencies of C1 inhibitor produce susceptibility to recurrent attacks of angioedema.
Catalogue Number	204883
Brand Family	Calbiochem®

References
References	Bowen, B., et al. 2001. Clin. Immunol. 98, 157. Davis, A.E. 1988. Ann. Rev. Immunol. 6, 595.

Product Information
Form	Liquid
Formulation	In PBS, pH 7.3, sterile-filtered through a 0.22 µm filter.
Preservative	None
Quality Level	MQ100

Applications
Application Comments	Variables associated with assay conditions will dictate the proper working dilution.

Biological Information
Biological activity	≥80% of C1-esterase inhibitor will bind activated C1s.
Purity	≥90% by SDS-PAGE
Source	Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information
Contaminants	IgG, IgA, IgM, albumin, C3, C4, or ceruloplasmin: ≤trace amounts

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	≤ -70°C
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).

Global Trade Item Number
Catalogue Number	GTIN
204883-1MG	04055977219777

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