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219477 Cdk4 Inhibitor II, NSC 625987 - CAS 141992-47-4 - Calbiochem

The Cdk4 Inhibitor II, NSC 625987, also referenced under CAS 141992-47-4, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,4-Dimethoxyacridine-9(10H)-thione

Primary Target: CDK4/D1
219477
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
141992-47-4C₁₅H₁₃NO₂S

Products

Catalogue NumberPackaging Qty/Pack
219477-5MG Glass bottle 5 mg
Description
OverviewA thioacridone compound that acts as a reversible and potent substrate-competitive inhibitor of Cdk4/cyclin D1 (IC50 = 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC50 > 100 µM).
Catalogue Number219477
Brand Family Calbiochem®
Synonyms1,4-Dimethoxyacridine-9(10H)-thione
References
ReferencesKubo, A., et al. 1999. Clin. Cancer Res. 5, 4279.
Product Information
CAS number141992-47-4
ATP CompetitiveN
FormBrown solid
Hill FormulaC₁₅H₁₃NO₂S
Chemical formulaC₁₅H₁₃NO₂S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCDK4/D1
Primary Target IC<sub>50</sub>200 nM against CDK4/D1
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
219477-5MG 04055977218541

Documentation

Cdk4 Inhibitor II, NSC 625987 - CAS 141992-47-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cdk4 Inhibitor II, NSC 625987 - CAS 141992-47-4 - Calbiochem Certificates of Analysis

TitleLot Number
219477

References

Reference overview
Kubo, A., et al. 1999. Clin. Cancer Res. 5, 4279.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-December-2009 RFH
Synonyms1,4-Dimethoxyacridine-9(10H)-thione
DescriptionA potent, reversible, and substrate-competitive inhibitor of Cdk4/cyclin D1 (IC50 = 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC50 >100 µM).
FormBrown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number141992-47-4
Chemical formulaC₁₅H₁₃NO₂S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (25 mg/ml) or Ethanol (2.5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesKubo, A., et al. 1999. Clin. Cancer Res. 5, 4279.