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400011 Caspase-1 Inhibitor I, Cell-Permeable - Calbiochem

Caspase-1 Inhibitor I, Cell-Permeable, inhibits the activity of caspase-1 (Ki = 1 nM), 4 & 5. The N-terminal corresponds to the h-region of the signal peptide of K-FGF that confers cell-permeabili

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Synonyms: ICE Inhibitor I, Cell-permeable, YVAD-CHO, Cell-permeable, Ac-AAVALLPAVLLALLAPYVAD-CHO

Primary Target: Caspase-1
400011
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Overview

Key Spec Table

Empirical Formula
C₉₇H₁₆₀N₂₀O₂₄

Products

Catalogue NumberPackaging Qty/Pack
400011-1MG Plastic ampoule 1 mg
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Description
OverviewA cell-permeable inhibitor of caspase-1 (ICE; Interleukin-1β Converting Enzyme), caspase-4, and caspase-5. The C-terminal YVAD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-1 (Ki = 1 nM). The N-terminal sequence (amino acid residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of the Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.
Catalogue Number400011
Brand Family Calbiochem®
SynonymsICE Inhibitor I, Cell-permeable, YVAD-CHO, Cell-permeable, Ac-AAVALLPAVLLALLAPYVAD-CHO
References
ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
Reiter, L.A. 1994. Int. J. Pept. Protein Res. 43, 87.
Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.
Thornberry, N.A., et al. 1994. Methods Enzymol. 244, 615.
Thornberry, N.A., et al. 1992. Nature 356, 768.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₉₇H₁₆₀N₂₀O₂₄
Chemical formulaC₉₇H₁₆₀N₂₀O₂₄
ReversibleY
Quality LevelMQ100
Applications
ApplicationCaspase-1 Inhibitor I, Cell-Permeable, inhibits the activity of caspase-1 (Ki = 1 nM), 4 & 5. The N-terminal corresponds to the h-region of the signal peptide of K-FGF that confers cell-permeability.
Biological Information
Primary TargetCaspase-1
Primary Target K<sub>i</sub>1 nM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Tyr-Val-Ala-Asp-CHO
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Global Trade Item Number
Catalogue Number GTIN
400011-1MG 04055977212624