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GF320 CD40 Ligand, Human Recombinant
Animal Free

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
UniProt Number: P29965
GF320
50µg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

SourcePurity
Protein is expressed in E.coli.
The protein is manufactured without the use of any animal products/reagents and is considered Animal-Free and can be used in protocols where possible transmisson of animal viruses and contamination must be avoided.		Product endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Description
Catalogue NumberGF320
DescriptionCD40 Ligand, Human Recombinant
Animal Free
Alternate Names
  • CD154
  • CD40 LIGAND
  • CD40L
  • GP39
  • hCD40L
Background InformationCD40, a member of the TNF receptor superfamily, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to “immunodeficiency with hyper-IgM”, a disease characterized by failure to produce IgG, IgA and IgE.
Recombinant human soluble CD40 ligand is a 16.3 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CD40L.
References
Product Information
PresentationProduct is presented in 10mM Sodium Phosphate, pH 7.5 and is filtered through a 0.2 micron filter before lyophilization.
Quality LevelMQ100
Applications
Biological Information
PurityProduct endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
SourceProtein is expressed in E.coli.
The protein is manufactured without the use of any animal products/reagents and is considered Animal-Free and can be used in protocols where possible transmisson of animal viruses and contamination must be avoided.
UniProt Number
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceBioactivity assay:
Determined by its ability to stimulate the proliferation of HEK-BlueTM CD40 reporter cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at -20°C for up to 4 months from date of receipt Centrifuge the vial prior to opening.
Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein and store in working aliquots at -20°C.
Packaging Information
Material Size50µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
GF320 04053252979606

Documentation

CD40 Ligand, Human Recombinant
Animal Free SDS

Title

Safety Data Sheet (SDS) 

CD40 Ligand, Human Recombinant
Animal Free Certificates of Analysis

TitleLot Number
CD40 Ligand, Human Recombinant Animal Free - Q2441379 Q2441379
CD40 Ligand, Human Recombinant - 3194587 3194587
CD40 Ligand, Human Recombinant -2803639 2803639
CD40 Ligand, Human Recombinant Animal Free - 3197624 3197624
CD40 Ligand, Human Recombinant Animal Free - 3442489 3442489
CD40 Ligand, Human Recombinant Animal Free - 3463554 3463554
CD40 Ligand, Human Recombinant Animal Free - 3928096 3928096
CD40 Ligand, Human Recombinant Animal Free - 4119027 4119027
CD40 Ligand, Human Recombinant Animal Free Recombinant Protein 2984164
CD40 Ligand, Human Recombinant Animal Free Recombinant Protein 2898241

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