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211200 CAPE - CAS 104594-70-9 - Calbiochem

A cell-permeable active component of propolis from honeybee hives.

CAPE - CAS 104594-70-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Caffeic Acid Phenethyl Ester, Synthetic

Primary Target: HIV-integrase
211200
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
104594-70-9C₁₇H₁₆O₄

Products

Catalogue NumberPackaging Qty/Pack
211200-25MG Plastic ampoule 25 mg
Description
OverviewA cell-permeable active component of propolis from honeybee hives. Known to have antiviral, anti-inflammatory, and immunomodulatory properties. Has also recently been shown to act as a potent and specific inhibitor of NF-κB activation. An inhibitor of HIV-1 integrase activity. Inhibits the growth of different types of transformed cells. Has been reported to suppress lipid peroxidation. Inhibits ornithine decarboxylase, protein tyrosine kinase (PTK), and lipoxygenase activities. Also induces apoptosis in cloned rat embryo fibroblast (CREF) cells transformed by a number of different oncogenes.
Catalogue Number211200
Brand Family Calbiochem®
SynonymsCaffeic Acid Phenethyl Ester, Synthetic
References
ReferencesNicklaus, M.C., et al. 1997. J. Med. Chem. 40, 920.
Natarajan, K., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 9090.
Burke, T.R., Jr., et al. 1995. J. Med. Chem. 38, 4171.
Laranjinha, J., et al. 1995. Arch. Biochem. Biophys. 323, 373.
Su, Z.-Z., et al. 1995. Anticancer Res. 15, 1841.
Zheng, Z.S., et al. 1995. Oncol. Res. 7, 445.
Su, Z.-Z., et al. 1994. Cancer Res. 54, 1865.
Fesen, M.R., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2399.
Guarini, L., et al. 1992. Cell. Mol. Biol. 38, 513.
Product Information
CAS number104594-70-9
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₁₇H₁₆O₄
Chemical formulaC₁₇H₁₆O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetHIV-integrase
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
211200-25MG 07790788048525

Documentation

CAPE - CAS 104594-70-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

CAPE - CAS 104594-70-9 - Calbiochem Certificates of Analysis

TitleLot Number
211200

References

Reference overview
Nicklaus, M.C., et al. 1997. J. Med. Chem. 40, 920.
Natarajan, K., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 9090.
Burke, T.R., Jr., et al. 1995. J. Med. Chem. 38, 4171.
Laranjinha, J., et al. 1995. Arch. Biochem. Biophys. 323, 373.
Su, Z.-Z., et al. 1995. Anticancer Res. 15, 1841.
Zheng, Z.S., et al. 1995. Oncol. Res. 7, 445.
Su, Z.-Z., et al. 1994. Cancer Res. 54, 1865.
Fesen, M.R., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2399.
Guarini, L., et al. 1992. Cell. Mol. Biol. 38, 513.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-May-2008 RFH
SynonymsCaffeic Acid Phenethyl Ester, Synthetic
DescriptionA cell-permeable active component of propolis from honeybee hives. Known to have antiviral, anti-inflammatory, and immunomodulatory properties. An inhibitor of HIV-1 integrase activity. Inhibits the growth of different types of transformed cells. Has been reported to suppress lipid peroxidation. Inhibits ornithine decarboxylase, protein tyrosine kinase (PTK) and lipoxygenase activities. Also induces apoptosis in cloned rat embryo fibroblast (CREF) cells transformed by a number of different oncogenes. Has also recently been shown to act as a potent and specific inhibitor of NF-κB activation.
FormWhite to off-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number104594-70-9
Chemical formulaC₁₇H₁₆O₄
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (200 mg/ml) and Ethanol (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesNicklaus, M.C., et al. 1997. J. Med. Chem. 40, 920.
Natarajan, K., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 9090.
Burke, T.R., Jr., et al. 1995. J. Med. Chem. 38, 4171.
Laranjinha, J., et al. 1995. Arch. Biochem. Biophys. 323, 373.
Su, Z.-Z., et al. 1995. Anticancer Res. 15, 1841.
Zheng, Z.S., et al. 1995. Oncol. Res. 7, 445.
Su, Z.-Z., et al. 1994. Cancer Res. 54, 1865.
Fesen, M.R., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2399.
Guarini, L., et al. 1992. Cell. Mol. Biol. 38, 513.