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MABE270 Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1

Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1 is a mouse monoclonal antibody for detection of phospho STAT6 (Tyr641) also known as Signal transducer & activator of transcription 6, IL-4 Stat & has been validated in WB, FC.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: STAT6 UniProt Number: P42226
MABE270
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWB, FCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABE270
DescriptionAnti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1
Alternate Names
  • Signal transducer and activator of transcription 6
  • IL-4 Stat
Background InformationSignal transducer and activator of transcription 6 (STAT6) transduces signals from extracellular cytokines during adaptive immunity and has recently been found to be important in the innate immune response to viral infection. STAT6 is also involved in the attenuation of the Th1 and Th17 in the nephritogenic immune response. The consequence of STAT6 activity has been associated with the pathogenesis of autoimmune disease and has been found to be actively imported to the nucleus.
References
Product Information
FormatPurified
Control
  • NIH/3T3 cell lysates treated and untreated with PDGF
PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1 is a mouse monoclonal antibody for detection of phospho STAT6 (Tyr641) also known as Signal transducer & activator of transcription 6, IL-4 Stat & has been validated in WB, FC.
Key Applications
  • Western Blotting
  • Flow Cytometry
Application NotesFlow Cytometry Analysis: 2 µg/mL from a representative lot detected STAT6 in human peripheral blood leukocytes.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human STAT6 phosphorylated at (Tyr641).
EpitopePhosphorylated (Tyr641)
Clone19E2.1
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityThis antibody recognizes STAT6 phosphorylated at (Tyr641).
IsotypeIgG2aκ
Species Reactivity
  • Human
  • Mouse
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
Gene Symbol
  • STAT6
Modifications
  • Phosphorylation
Purification MethodProtein G Purified
UniProt Number
UniProt SummaryFUNCTION: Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.

SUBUNIT STRUCTURE: Forms a homodimer or a heterodimer with a related family member By similarity. Interacts with NCOA1 via its C-terminal LXXLL motif.

SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note: Translocated into the nucleus in response to phosphorylation.

PTM: Tyrosine phosphorylated following stimulation by IL-4 and IL-3 (By similarity).

SEQUENCE SIMILARITIES: Belongs to the transcription factor STAT family.

Contains 1 SH2 domain.
Molecular Weight~165 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in NIH/3T3 cell lysates treated and untreated with PDGF.

Western Blot Analysis: 0.5 µg/mL of this antibody detected STAT6 on 10 µg of PDGF untreated and treated NIH/3T3 cell lysates.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABE270 04053252686856

Documentation

Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1 SDS

Title

Safety Data Sheet (SDS) 

Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1 Certificates of Analysis

TitleLot Number
Anti-phospho STAT6 (Tyr641), -2636743 2636743
Anti-phospho STAT6 (Tyr641), -2686154 2686154
Anti-phospho STAT6 (Tyr641), clone 19E2.1 - 2204985 2204985
Anti-phospho STAT6 (Tyr641), clone 19E2.1 - 2290257 2290257
Anti-phospho STAT6 (Tyr641), clone 19E2.1 - 2349709 2349709
Anti-phospho STAT6 (Tyr641), clone 19E2.1 - 3901432 3901432
Anti-phospho STAT6 (Tyr641), clone 19E2.1 - N1956541 N1956541
Anti-phospho STAT6 (Tyr641), clone 19E2.1 Monoclonal Antibody 2981047
Anti-phospho STAT6 (Tyr641), clone 19E2.1 Monoclonal Antibody 3097348

Brochure

Title
New Products: Volume 3, 2012

Technical Info

Title
JAK/STAT Signaling Research Focus