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MABC1151 Anti-NY-ESO-1 Antibody, clone D8.38

Detect NY-ESO-1, LAGE-1 using this mouse monoclonal Anti-NY-ESO-1 antibody, clone D8.38, Cat. No. MABC1151. Validated for use in Immunohistochemistry (Paraffin).

Anti-NY-ESO-1 Antibody, clone D8.38 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Gene Symbol: CTAG1A, CTAG, CTAG1, ESO1, LAGE2, LAGE2A, CTAG1B, LAGE2B UniProt Number: P78358, O75638
MABC1151
100 µL  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HIH(P)MPurifiedMonoclonal Antibody
Description
Catalogue NumberMABC1151
DescriptionAnti-NY-ESO-1 Antibody, clone D8.38
Alternate Names
  • Cancer/testis antigen 1
  • Autoimmunogenic cancer/testis antigen NY-ESO-1
  • Cancer/testis antigen 6.1
  • CT6.1
  • L antigen family member 2
  • LAGE-2
Background InformationCancer/testis antigen 1 (UniProt: P78358; also known as Autoimmunogenic cancer/testis antigen NY-ESO-1, Cancer/testis antigen 6.1, CT6.1, L antigen family member 2, LAGE-2) is encoded by the CTAG1A (also known as CTAG, CTAG1, ESO1, LAGE2, LAGE2A, CTAG1B, LAGE2B) gene (Gene ID: 1485; 246100) in human. NY-ESO-1 is a human tumor antigen of the cancer/testis family that is highly expressed in many poor-prognosis melanomas and in other cancer types. However, it is not detected in non-malignant tissues with the exception of germ cells and trophoblasts. It contains a C-terminal hydrophobic tail that potentially serves as membrane-associated domain. NY-ESO-1 is expressed from 18 weeks until birth in human fetal testis and in adult testis it is strongly expressed in spermatogonia and in primary spermatocytes, but not in post-meiotic cells or in testicular somatic cells. Although the exact function of NY-ESO-1 is still not clear, it has been speculated it might contribute to certain properties, such as immortality, self-renewal, migratory ability, and capacity to invade that favor tumor cell survival. On the basis of its immunogenicity, NY-ESO-1 is considered as one of the most attractive antigens for cancer immunotherapy. T cells engineered to express an affinity-enhanced T cell receptor (TCR) recognizing a naturally processed peptide shared by the cancer-testis antigens NY-ESO-1 and LAGE-1 have been considered as an attractive method for treatment of myeloma and enhance long-term survival of cells.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect NY-ESO-1, LAGE-1 using this mouse monoclonal Anti-NY-ESO-1 antibody, clone D8.38, Cat. No. MABC1151. Validated for use in Immunohistochemistry (Paraffin).
Key Applications
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:250-1,000 dilution from a representative lot detected NY-ESO-1 in human testis tissue.

Immunohistochemistry Analysis: A representative lot detected NY-ESO-1 in Immunohistochemistry applications. (Yakirevich, E., et. al. (2003). Clin Cancer Res. 9(17):6453-60; Bujas, T., et. al. (2011). Eur J Histochem. 55(1):e7; Bolli, M., et. al. (2005). Int J Cancer. 115(6):960-6; Groeper, C., et. al. (2007). Int J Cancer. 120(2):337-43).
Biological Information
ImmunogenA full length recombinant human NY-ESO-1 protein.
Epitopedomain of:
CloneD8.38
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityClone D8.38 specifically targets a sequence in the N-terminal region and detects Cancer/testis antigen 1 (NY-ESO1) in human testis
IsotypeIgG1κ
Species Reactivity
  • Human
Species Reactivity NoteHuman.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • CTAG1A
  • CTAG
  • CTAG1
  • ESO1
  • LAGE2
  • LAGE2A
  • CTAG1B
  • LAGE2B
Purification MethodProtein G purified
UniProt Number
Molecular Weight17.99 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry in human testis tissue.

Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected NY-ESO-1 in human testis tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABC1151 04054839155963