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04-1584 Anti-Interleukin-2 (IL-2) Antibody, clone 3F9

Detect Interleukin-2 (IL-2) using this Anti-Interleukin-2 (IL-2) Antibody, clone 3F9 validated for use in WB.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Cytokines & Cytokine Receptors Gene Symbol: IL2, IL-2, TCGF UniProt Number: P60568
04-1584
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBMPurifiedMonoclonal Antibody
Description
Catalogue Number04-1584
DescriptionAnti-Interleukin-2 (IL-2) Antibody, clone 3F9
Alternate Names
  • interleukin 2
  • involved in regulation of T-cell clonal expansion
  • aldesleukin
  • T cell growth factor
  • lymphokine
  • Aldesleukin
  • interleukin-2
  • T-cell growth factor
Background InformationInterleukin-2 (IL-2) is commonly considered a pro-inflammatory cytokine that stimulated T-cell-dependent immune reactions and control regulatory T cells or Tregs. Structurally, IL-2 is thought to have a 4-helix-bundle-type fold and uses a novel type I cytokine receptor (IL-21R) with the common gamma chain cytokine receptor. IL-2 also may intensify Th1-mediated diseases, including autoimmune arthritis and may also be interesting clinical targets for those diseases. IL-2 has also been implicated as a possible therapy for infection and cancer. Anti-tumor therapies that include a combination of recombinant IL-2 and recombinant interferon alpha have been promising in clinical studies.
References
Product Information
FormatPurified
Control
  • Human IL-2 recombinant protein
PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect Interleukin-2 (IL-2) using this Anti-Interleukin-2 (IL-2) Antibody, clone 3F9 validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
ImmunogenFull length recombinant protein corresponding to human IL-2.
CloneAB12.38.35C3.3F9
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
IsotypeIgG2bκ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq].
Gene Symbol
  • IL2
  • IL-2
  • TCGF
Purification MethodProtein G Purified
UniProt Number
UniProt SummaryFUNCTION: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

SUBCELLULAR LOCATION: Secreted.

INVOLVEMENT IN DISEASE: Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

PHARMACEUTICAL USE: Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma.

SEQUENCE SIMILARITIES: Belongs to the IL-2 family.

SEQUENCE CAUTION: The sequence AAA59140.1 differs from that shown. Reason: Erroneous initiation.
Molecular Weight~15 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in lysate from cells expressing human IL-2 recombinant protein.

Western Blot Analysis: 0.5 µg/mL of this antibody detected 10 µg of human IL-2 recombinant protein.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
04-1584 04053252646102

Documentation

Anti-Interleukin-2 (IL-2) Antibody, clone 3F9 SDS

Title

Safety Data Sheet (SDS) 

Anti-Interleukin-2 (IL-2) Antibody, clone 3F9 Certificates of Analysis

TitleLot Number
Anti-Interleukin-2 (IL-2), clone 3F9 - 2073636 2073636
Anti-Interleukin-2 (IL-2), clone 3F9 - 3494044 3494044
Anti-Interleukin-2 (IL-2), clone 3F9 - NRG1843057 NRG1843057
Anti-Interleukin-2 (IL-2), clone 3F9 -2567156 2567156
Anti-Interleukin-2 (IL-2), clone 3F9 -2659576 2659576
Anti-Interleukin-2 (IL-2), clone 3F9 -2665773 2665773
Anti-Interleukin-2 (IL-2), clone 3F9 -2708943 2708943
Anti-Interleukin-2 (IL-2), clone 3F9 -2786326 2786326
Anti-Interleukin-2 (IL-2), clone 3F9 Monoclonal Antibody 3030316
Anti-Interleukin-2 (IL-2), clone 3F9 Monoclonal Antibody 3137668