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MABN226 Anti-DENR Antibody, clone 10D9.1

Anti-DENR Antibody, clone 10D9.1 is a mouse monoclonal antibody, validated for use in western blotting & IHC.

Anti-DENR Antibody, clone 10D9.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: DENR, DRP1, H14 UniProt Number: O43583
MABN226
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, RWB, IHCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABN226
DescriptionAnti-DENR Antibody, clone 10D9.1
Alternate Names
  • Density-regulated protein
  • DRP
  • Protein DRP1
  • Smooth muscle cell-associated protein 3
  • SMAP-3
Background InformationThe protein named density-regulated protein (DRP1), also known as DRP, or Protein DRP1 or Smooth muscle cell-associated protein 3 (SMAP-3), and encoded by the gene DENR/DRP1, is an important translational control protein that appears to function by scanning target mRNAs for the recognition codon when complexed with the translational initiation complex. DRP1 also modulates the translation of particular cancer-related mRNAs when recruited to the translational complex by the oncogene MCTS1 and DRP1 is up regulated in many cancers such as ovarian and breast cancers. Additionally, DRP1’s expression is regulated by increasing cell density through interaction with heterogeneous nuclear ribonucleoprotein D (HNRNPD) protein, a critical protein that complexes with heterogeneous nuclear RNA and pre-mRNAs and fosters mRNA stability. Density-regulated protein (DRP1) is localized to the in heart, skeletal muscle, brain, placenta, liver and pancreas, with weaker expression seen in lung and kidney.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-DENR Antibody, clone 10D9.1 is a mouse monoclonal antibody, validated for use in western blotting & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected DENR in human cerebral cortex and human cardiac myocytes tissue.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to the C-terminus of human DENR.
EpitopeC-terminus
Clone10D9.1
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
IsotypeIgG2aκ
Species Reactivity
  • Human
  • Rat
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • DENR
  • DRP1
  • H14
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~22 kDa observed. Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in PC-12 cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected DENR in 10 µg of PC-12 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABN226 04053252938559