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MABT1526-25UG Anti-Cadherin 17 Antibody, clone 7C5

Anti-Cadherin 17, clone 7C5, Cat. No. MABT1526, is a mouse monoclonal antibody that detects Cadherin 17 and has been tested for use in Immunohistochemistry (Paraffin).

MABT1526-25UG
25 μg  
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue NumberMABT1526-25UG
DescriptionAnti-Cadherin 17 Antibody, clone 7C5
Alternate Names
  • Intestinal peptide-associated transporter HPT-1
  • Liver-intestine cadherin
  • LI-cadherin
Background InformationCadherin 17 (UniProt: Q12864; also known as Intestinal peptide-associated transporter HPT-1, Liver-intestine cadherin, LI-cadherin) is encoded by the CDH17 gene (Gene ID: 1015) in human. Cadherins are calcium-dependent cell adhesion molecules that participate in cell-cell adhesion during embryogenesis, development, organogenesis, and differentiation. Cadherin 17 is a single-pass type I membrane glycoprotein. It is predominantly expressed in the gastrointestinal tract and pancreatic duct and is not detected in kidney, lung, liver, brain, adrenal gland, and skin. It is synthesized with a signal peptide (aa 1-22), which is cleaved off to generate the mature form that contains an extracellular domain (aa 23-787), transmembrane domain (aa 788-808), and a cytoplasmic domain (aa 809-832). It differs from classical cadherins in having a short cytoplasmic tail at its carboxyl-terminus. In the extracellular region it has 7 cadherin domains. Three calcium ions are usually bound at the interface of each cadherin domain that rigidify the connections, imparting a strong curvature to the full-length ectodomain. Cadherin-17 expression has been described in several gastric carcinomas and it is shown to be a good immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system. It is considered as an oncofetal molecule associated with poor prognostic outcomes of hepatocellular carcinoma. (Ref.: Wang, Y., et al. (2013). PLoS One. 8(9); e72386).
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
ApplicationAnti-Cadherin 17, clone 7C5, Cat. No. MABT1526, is a mouse monoclonal antibody that detects Cadherin 17 and has been tested for use in Immunohistochemistry (Paraffin).
Key Applications
  • Immunohistochemistry (Paraffin)
Biological Information
ImmunogenRecombinant human Cadherin 17-Fc Protein.
Epitopeextracellular domain
Clone7C5
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityClone 7C5 is a a mouse monoclonal antibody that detects human Cadherin 17.
IsotypeIgG2aκ
Species Reactivity
  • Human
Species Reactivity NoteHuman.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • CDH17
Purification MethodProtein G purified
UniProt Number
Molecular Weight92.22 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry (Paraffin) in human small intestine tissue sections.

Immunohistochemistry (Paraffin) Analysis: A 1:250 dilution of this antibody detected Cadherin 17 in human small intestine tissue sections.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size25 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABT1526-25UG 04061841235958