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AB15708A4 Sigma-AldrichAnti-Beta III Tubulin Antibody, Alexa Fluor® 488 Conjugate

Anti-Beta III Tubulin Antibody, Alexa Fluor 488 Conjugate is an antibody against Beta III Tubulin for use in IC, IH.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Research Category: Neuroscience Research Sub-Category: Neurofilament & Neuron Metabolism Gene Symbol: TUBB3, TUBB4, MC1R, beta-4 UniProt Number: Q13509

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Key Spec Table

Species Reactivity	Key Applications	Host	Format	Antibody Type
R, M, H	ICC, IHC	Rb	AlexaFluor®488	Polyclonal Antibody

Description
Catalogue Number	AB15708A4
Description	Anti-Beta III Tubulin Antibody, Alexa Fluor® 488 Conjugate
Alternate Names	Tubulin beta-4 Tubulin beta-III tubulin, beta 3 tubulin, beta, 4
Background Information	Tubulin is one of several members of a small family of globular proteins which polymerize to form cytoskeletal structures called microtubules. The most common members of the tubulin family are α-tubulin and β-tubulin. Tubulin dimers, typically composed of α- and β-tubulin subunits, assemble onto microtubules forming large polymers. β-III tubulin is a unique microtubule subunit that is found expressed almost exclusively in neurons. Due to the unique expression pattern of β-III tubulin it is often utilized as a marker to identify neuronal cells from other brain cells such as glia which do not express it. β-III tubulin also serves as a cytoarchitectural marker since it is primarily found within neurite extensions.

References

Product Information
Format	AlexaFluor®488
Control	Rat E18 cortex cells
Presentation	Purified rabbit polyclonal conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Quality Level	MQ100

Applications
Application	Anti-Beta III Tubulin Antibody, Alexa Fluor 488 Conjugate is an antibody against Beta III Tubulin for use in IC, IH.
Key Applications	Immunocytochemistry Immunohistochemistry
Application Notes	Immunohistochemistry: Representive lot has been shown to work in adult mouse brain.

Biological Information
Immunogen	Synthetic linear peptide corresponding to human Beta III Tubulin.
Host	Rabbit
Specificity	This antibody recognizes Beta III Tubulin.
Species Reactivity	Rat Mouse Human
Species Reactivity Note	Demonstrated to react with Rat and Mouse. Predicted to react with Human based on 100% sequence homology.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_006077
Entrez Gene Summary	This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6.
Gene Symbol	TUBB3 TUBB4 MC1R beta-4
Purification Method	Affinity Purfied
UniProt Number	Q13509
UniProt Summary	FUNCTION: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. SIZE: 450 amino acids; 50433 Da SUBUNIT: Dimer of alpha and beta chains. DOMAIN: The highly acidic C-terminal region may bind cations such as calcium. SIMILARITY: Belongs to the tubulin family.
Molecular Weight	50 kDa calculated

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Immunocytochemistry in rat E18 cortex cells. Immunocytochemistry Analysis: A 1:400 dilution of this antibody detected Beta III Tubulin in rat E18 cortex cells.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalogue Number	GTIN
AB15708A4	04053252754968

Documentation

Anti-Beta III Tubulin Antibody, Alexa Fluor® 488 Conjugate SDS

Title
Safety Data Sheet (SDS)

Anti-Beta III Tubulin Antibody, Alexa Fluor® 488 Conjugate Certificates of Analysis

Title	Lot Number
Anti-Beta III Tubulin, Alexa Fluor#174; 488 Conjugate - 2031358	2031358
Anti-Beta III Tubulin, Alexa Fluor#174; 488 Conjugate - 2107282	2107282
Anti-Beta III Tubulin, Alexa Fluor#174; 488 Conjugate - 2224452	2224452
Anti-Beta III Tubulin, Alexa Fluor® 488 -2568149	2568149
Anti-Beta III Tubulin, Alexa Fluor® 488 -2806123	2806123
Anti-Beta III Tubulin, Alexa Fluor® 488 Conjugate	3030312
Anti-Beta III Tubulin, Alexa Fluor® 488 Conjugate	2967905
Anti-Beta III Tubulin, Alexa Fluor® 488 Conjugate	2890907
Anti-Beta III Tubulin, Alexa Fluor® 488 Conjugate	2884285
Anti-Beta III Tubulin, Alexa Fluor® 488 Conjugate - 2424823	2424823

Related Products & Applications

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AB15708	Anti-β III tubulin Antibody
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AB9354	Anti-Beta III Tubulin Antibody
CBL412A5	Anti-Tubulin β-III Antibody, clone TU-20, Alexa Fluor®555 Conjugate
CBL412X	Anti-Tubulin β-III Antibody, clone TU-20, Alexa Fluor®488 Conjugated
MAB1637	Anti-Tubulin Antibody, beta III isoform, CT, clone TU-20 (Similar to TUJ1)
MAB3408	Anti-Tubulin Antibody, beta, clone KMX-1
MAB380	Anti-Tubulin β Antibody, clone 5H1
MAB5564	Anti-Tubulin β III Antibody

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